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The Challenge of Treatment in Potential Celiac Disease
Joint Authors
Cucchiara, Salvatore
Oliva, Salvatore
Valitutti, Francesco
Trovato, Chiara Maria
Montuori, Monica
Leter, Beatrice
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Potential celiac disease (PCD) is defined by the presence of positive serum antibodies, HLA-DQ2/DQ8 haplotypes, and a normal small intestinal mucosa (Marsh grade 0-1).
This condition occurs in one-fifth of celiac disease (CD) patients and usually represents a clinical challenge.
We reviewed genetic, histologic, and clinical features of this specific condition by performing a systematic search on MEDLINE, Embase, and Scholar database.
Accordingly, we identified different genetic features in patients with PCD compared to the classical forms.
Frequently, signs of inflammation (deposits of immunoglobulin A (IgA) and/or increased number of intraepithelial lymphocytes) can be clearly identify in the mucosa of PCD patients after an accurate histological assessment.
Finally, the main challenge is represented by the treatment: the gluten-free diet should be considered only in the presence of gluten-dependent symptoms in both children and adults.
What is known: (i) potential celiac disease (PCD) occurs in one-fifth of all celiac diseases (CD), and (ii) despite the absence of classical lesions, clear signs of inflammation are often detectable.
What is new: (i) patients with PCD show different genetic features, and (ii) the presence of gluten-dependent symptoms is the main determinant to initiate the gluten-free diet, after a complete diagnostic work-up.
American Psychological Association (APA)
Trovato, Chiara Maria& Montuori, Monica& Valitutti, Francesco& Leter, Beatrice& Cucchiara, Salvatore& Oliva, Salvatore. 2019. The Challenge of Treatment in Potential Celiac Disease. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1155540
Modern Language Association (MLA)
Trovato, Chiara Maria…[et al.]. The Challenge of Treatment in Potential Celiac Disease. Gastroenterology Research and Practice No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1155540
American Medical Association (AMA)
Trovato, Chiara Maria& Montuori, Monica& Valitutti, Francesco& Leter, Beatrice& Cucchiara, Salvatore& Oliva, Salvatore. The Challenge of Treatment in Potential Celiac Disease. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1155540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155540