Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLCESI-Q-TOF Mass Spectrometry
المؤلفون المشاركون
Hur, Haeng Jeon
Sung, Mi Jeong
Choi, Jung Hoon
Hwang, In Koo
Jang, Gwang-Ju
Yoo, Miyoung
Lee, Sanghee
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Hyperlipidemia is a risk factor for atherosclerotic cardiovascular disease and is a major public health concern.
Allium hookeri (AH) is an Allium species containing high levels of bioactive organosulfur compounds such as methiin and cycloalliin.
AH exerts hypolipidemic effects in animals fed a high-fat diet.
However, there exists little information on the mechanisms underlying these effects.
To address this issue, we used a metabolomic approach based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry to identify factors mediating the lipid-lowering effects of AH.
Principal component and partial least-squares discriminant analyses of serum metabolome profiles revealed 25 metabolites as potential biomarkers for the effects of AH on lipid levels.
These compounds were predominantly phospholipids, including phosphatidylcholines (PCs), lysoPCs, and lysophosphatidylethanolamines.
Glycerophospholipid metabolism was identified as a significantly enriched pathway.
These results provide mechanistic insight into the antihyperlipidemic effects of AH and evidence for its efficacy as a therapeutic agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jang, Gwang-Ju& Sung, Mi Jeong& Hur, Haeng Jeon& Yoo, Miyoung& Choi, Jung Hoon& Hwang, In Koo…[et al.]. 2018. Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLCESI-Q-TOF Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155581
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jang, Gwang-Ju…[et al.]. Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLCESI-Q-TOF Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1155581
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jang, Gwang-Ju& Sung, Mi Jeong& Hur, Haeng Jeon& Yoo, Miyoung& Choi, Jung Hoon& Hwang, In Koo…[et al.]. Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLCESI-Q-TOF Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155581
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155581
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر