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Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLCESI-Q-TOF Mass Spectrometry
Joint Authors
Hur, Haeng Jeon
Sung, Mi Jeong
Choi, Jung Hoon
Hwang, In Koo
Jang, Gwang-Ju
Yoo, Miyoung
Lee, Sanghee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hyperlipidemia is a risk factor for atherosclerotic cardiovascular disease and is a major public health concern.
Allium hookeri (AH) is an Allium species containing high levels of bioactive organosulfur compounds such as methiin and cycloalliin.
AH exerts hypolipidemic effects in animals fed a high-fat diet.
However, there exists little information on the mechanisms underlying these effects.
To address this issue, we used a metabolomic approach based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry to identify factors mediating the lipid-lowering effects of AH.
Principal component and partial least-squares discriminant analyses of serum metabolome profiles revealed 25 metabolites as potential biomarkers for the effects of AH on lipid levels.
These compounds were predominantly phospholipids, including phosphatidylcholines (PCs), lysoPCs, and lysophosphatidylethanolamines.
Glycerophospholipid metabolism was identified as a significantly enriched pathway.
These results provide mechanistic insight into the antihyperlipidemic effects of AH and evidence for its efficacy as a therapeutic agent.
American Psychological Association (APA)
Jang, Gwang-Ju& Sung, Mi Jeong& Hur, Haeng Jeon& Yoo, Miyoung& Choi, Jung Hoon& Hwang, In Koo…[et al.]. 2018. Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLCESI-Q-TOF Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155581
Modern Language Association (MLA)
Jang, Gwang-Ju…[et al.]. Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLCESI-Q-TOF Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1155581
American Medical Association (AMA)
Jang, Gwang-Ju& Sung, Mi Jeong& Hur, Haeng Jeon& Yoo, Miyoung& Choi, Jung Hoon& Hwang, In Koo…[et al.]. Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLCESI-Q-TOF Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155581