Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK12 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat
المؤلفون المشاركون
Guo, Zhuang-Li
Aori, Gele
Wang, Qi
Kong, Dawei
Yang, Wenqiang
Zhang, Li
Yu, Yan-Bing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Danhong injection (DHI) has been widely used in China for cardiocerebrovascular diseases treatments.
And in this study, we demonstrated the therapeutic effect of DHI on experimental diabetic neuropathy for the first time.
Methods.
Streptozotocin- (STZ-) induced SD rats were used.
In experiment 1, 4-week treatment with DHI or saline started 4 weeks after STZ injection; mechanical allodynia was measured before and every 2 weeks after STZ injection.
In experiment 2, chronic intrathecal infusion of U0126 was conducted during the 8th week of diabetes.
Phosphorylated and total ERK1/2 in spinal cord were analyzed by western blot.
BDNF level in sciatic nerve was evaluated by ELISA.
Results.
DHI treatment significantly alleviated mechanical allodynia at the end of the study and downregulated the expression of phosphorylated ERK1/2 in spinal cord.
In addition, DHI treatment also elevated brain-derived neurotrophic factor (BDNF) level in sciatic nerve of DPN rat.
In experiment 2, inhibition of ERK1/2 activation was confirmed to result in the alleviation of mechanical allodynia.
Conclusions.
We demonstrated that DHI was able to alleviate mechanical allodynia in diabetic neuropathy rat through inhibiting the activation of ERK1/2.
The reduction of BDNF content in sciatic nerve was also partially reversed by DHI treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Qi& Guo, Zhuang-Li& Aori, Gele& Kong, Dawei& Yang, Wenqiang& Zhang, Li…[et al.]. 2018. Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK12 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1155624
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Qi…[et al.]. Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK12 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1155624
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Qi& Guo, Zhuang-Li& Aori, Gele& Kong, Dawei& Yang, Wenqiang& Zhang, Li…[et al.]. Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK12 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1155624
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155624
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر