Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK12 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat
Joint Authors
Guo, Zhuang-Li
Aori, Gele
Wang, Qi
Kong, Dawei
Yang, Wenqiang
Zhang, Li
Yu, Yan-Bing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Danhong injection (DHI) has been widely used in China for cardiocerebrovascular diseases treatments.
And in this study, we demonstrated the therapeutic effect of DHI on experimental diabetic neuropathy for the first time.
Methods.
Streptozotocin- (STZ-) induced SD rats were used.
In experiment 1, 4-week treatment with DHI or saline started 4 weeks after STZ injection; mechanical allodynia was measured before and every 2 weeks after STZ injection.
In experiment 2, chronic intrathecal infusion of U0126 was conducted during the 8th week of diabetes.
Phosphorylated and total ERK1/2 in spinal cord were analyzed by western blot.
BDNF level in sciatic nerve was evaluated by ELISA.
Results.
DHI treatment significantly alleviated mechanical allodynia at the end of the study and downregulated the expression of phosphorylated ERK1/2 in spinal cord.
In addition, DHI treatment also elevated brain-derived neurotrophic factor (BDNF) level in sciatic nerve of DPN rat.
In experiment 2, inhibition of ERK1/2 activation was confirmed to result in the alleviation of mechanical allodynia.
Conclusions.
We demonstrated that DHI was able to alleviate mechanical allodynia in diabetic neuropathy rat through inhibiting the activation of ERK1/2.
The reduction of BDNF content in sciatic nerve was also partially reversed by DHI treatment.
American Psychological Association (APA)
Wang, Qi& Guo, Zhuang-Li& Aori, Gele& Kong, Dawei& Yang, Wenqiang& Zhang, Li…[et al.]. 2018. Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK12 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1155624
Modern Language Association (MLA)
Wang, Qi…[et al.]. Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK12 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1155624
American Medical Association (AMA)
Wang, Qi& Guo, Zhuang-Li& Aori, Gele& Kong, Dawei& Yang, Wenqiang& Zhang, Li…[et al.]. Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK12 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1155624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155624