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Zishenwan Decreases Kidney Damage in Recurrent Urinary Tract Infection through the Inhibition of Toll-Like Receptor 4 Signal
المؤلفون المشاركون
Jiang, Chunbo
Liang, Guoqiang
Ren, Yan
Song, Yongliang
Jin, Weimin
Tang, Hua
Ni, Daolei
Zhang, Chenxi
Zheng, Wenyi
Shen, Xiaofeng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives.
To investigate the mechanism of the protective effect of Zishenwan on pyelonephritis rats.
Methods.
In the rat model of pyelonephritis, protective effects of Zishenwan, the content of secretory immunoglobulin A (SIg A), and interleukins were detected by ELISA.
The expressions of TLR4-NFκB pathway were detected by Western blot in renal and urinary tract mucosa.
The protective effect and influence on TLR4-NFκB pathway of Zishenwan were studied.
Results.
Zishenwan protected rats from pyelonephritis which related to the increase of SIgA, the regulation of interleukins, and the inhibition of TLR4-NFκB pathway.
Serum containing Zishenwan can significantly decrease LPS-induced expression of TLR4, MyD88, and NFκB in vitro.
And the inhibition of TLR4 signal by Zishenwan related to the degradation of TRAF3 and TRAF6.
Conclusions.
Zishenwan protected rats from urinary tract infection by clearance of bacteria and decrease of tissue damage.
20S proteasomes mediated the degradation of TRAF3 which is important to the decrease of tissue damage from Zishenwan.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Guoqiang& Tang, Hua& Ni, Daolei& Ren, Yan& Zhang, Chenxi& Zheng, Wenyi…[et al.]. 2018. Zishenwan Decreases Kidney Damage in Recurrent Urinary Tract Infection through the Inhibition of Toll-Like Receptor 4 Signal. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155708
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Guoqiang…[et al.]. Zishenwan Decreases Kidney Damage in Recurrent Urinary Tract Infection through the Inhibition of Toll-Like Receptor 4 Signal. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155708
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Guoqiang& Tang, Hua& Ni, Daolei& Ren, Yan& Zhang, Chenxi& Zheng, Wenyi…[et al.]. Zishenwan Decreases Kidney Damage in Recurrent Urinary Tract Infection through the Inhibition of Toll-Like Receptor 4 Signal. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155708
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155708
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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