Zishenwan Decreases Kidney Damage in Recurrent Urinary Tract Infection through the Inhibition of Toll-Like Receptor 4 Signal
Joint Authors
Jiang, Chunbo
Liang, Guoqiang
Ren, Yan
Song, Yongliang
Jin, Weimin
Tang, Hua
Ni, Daolei
Zhang, Chenxi
Zheng, Wenyi
Shen, Xiaofeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
To investigate the mechanism of the protective effect of Zishenwan on pyelonephritis rats.
Methods.
In the rat model of pyelonephritis, protective effects of Zishenwan, the content of secretory immunoglobulin A (SIg A), and interleukins were detected by ELISA.
The expressions of TLR4-NFκB pathway were detected by Western blot in renal and urinary tract mucosa.
The protective effect and influence on TLR4-NFκB pathway of Zishenwan were studied.
Results.
Zishenwan protected rats from pyelonephritis which related to the increase of SIgA, the regulation of interleukins, and the inhibition of TLR4-NFκB pathway.
Serum containing Zishenwan can significantly decrease LPS-induced expression of TLR4, MyD88, and NFκB in vitro.
And the inhibition of TLR4 signal by Zishenwan related to the degradation of TRAF3 and TRAF6.
Conclusions.
Zishenwan protected rats from urinary tract infection by clearance of bacteria and decrease of tissue damage.
20S proteasomes mediated the degradation of TRAF3 which is important to the decrease of tissue damage from Zishenwan.
American Psychological Association (APA)
Liang, Guoqiang& Tang, Hua& Ni, Daolei& Ren, Yan& Zhang, Chenxi& Zheng, Wenyi…[et al.]. 2018. Zishenwan Decreases Kidney Damage in Recurrent Urinary Tract Infection through the Inhibition of Toll-Like Receptor 4 Signal. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155708
Modern Language Association (MLA)
Liang, Guoqiang…[et al.]. Zishenwan Decreases Kidney Damage in Recurrent Urinary Tract Infection through the Inhibition of Toll-Like Receptor 4 Signal. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155708
American Medical Association (AMA)
Liang, Guoqiang& Tang, Hua& Ni, Daolei& Ren, Yan& Zhang, Chenxi& Zheng, Wenyi…[et al.]. Zishenwan Decreases Kidney Damage in Recurrent Urinary Tract Infection through the Inhibition of Toll-Like Receptor 4 Signal. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155708