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Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats
المؤلفون المشاركون
Choi, Ho-Young
Kim, Bumjung
Jo, Cheolmin
Lee, Kyungjin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Historically, traditional herbal medicines (THMs) have been the conventional treatment strategy in the Korean medical system for treating many diseases.
However, THMs have rarely been used to treat hypertension, and moreover few studies have investigated the interaction of blood pressure with the coadministration of synthetic antihypertensives.
We aimed to evaluate the vasorelaxant and hypotensive effects of the traditional herbal prescription Cheonwangbosimdan (CWBSD; “Tianwangbuxindan” in Chinese) and the combination of CWBSD with amlodipine.
CWBSD was extracted with distilled water at 100°C for 2 h.
To investigate vasorelaxant activities, CWBSD with amlodipine (10 μg/ml) was added cumulatively (10–1,000 μg/ml) to isolated rat aortic rings precontracted using phenylephrine or potassium chloride in organ chambers.
To investigate hypotensive effects, CWBSD (2,476 mg/kg) was orally administered with or without amlodipine (5 mg/kg) to spontaneously hypertensive rats (SHRs).
CWBSD increased the relaxation of rat aortic rings induced by amlodipine (P < 0.01).
In vivo, CWBSD coadministration with amlodipine also significantly decreased the blood pressure of SHRs compared to the amlodipine-treated group.
These results suggested that CWBSD could be a useful herbal prescription to treat hypertension and we recommend establishing guidelines for the use of herbal medicines in conjunction with antihypertensive drugs, including amlodipine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Bumjung& Jo, Cheolmin& Choi, Ho-Young& Lee, Kyungjin. 2018. Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155773
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Bumjung…[et al.]. Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1155773
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Bumjung& Jo, Cheolmin& Choi, Ho-Young& Lee, Kyungjin. Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155773
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155773
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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