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Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats
Joint Authors
Choi, Ho-Young
Kim, Bumjung
Jo, Cheolmin
Lee, Kyungjin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Historically, traditional herbal medicines (THMs) have been the conventional treatment strategy in the Korean medical system for treating many diseases.
However, THMs have rarely been used to treat hypertension, and moreover few studies have investigated the interaction of blood pressure with the coadministration of synthetic antihypertensives.
We aimed to evaluate the vasorelaxant and hypotensive effects of the traditional herbal prescription Cheonwangbosimdan (CWBSD; “Tianwangbuxindan” in Chinese) and the combination of CWBSD with amlodipine.
CWBSD was extracted with distilled water at 100°C for 2 h.
To investigate vasorelaxant activities, CWBSD with amlodipine (10 μg/ml) was added cumulatively (10–1,000 μg/ml) to isolated rat aortic rings precontracted using phenylephrine or potassium chloride in organ chambers.
To investigate hypotensive effects, CWBSD (2,476 mg/kg) was orally administered with or without amlodipine (5 mg/kg) to spontaneously hypertensive rats (SHRs).
CWBSD increased the relaxation of rat aortic rings induced by amlodipine (P < 0.01).
In vivo, CWBSD coadministration with amlodipine also significantly decreased the blood pressure of SHRs compared to the amlodipine-treated group.
These results suggested that CWBSD could be a useful herbal prescription to treat hypertension and we recommend establishing guidelines for the use of herbal medicines in conjunction with antihypertensive drugs, including amlodipine.
American Psychological Association (APA)
Kim, Bumjung& Jo, Cheolmin& Choi, Ho-Young& Lee, Kyungjin. 2018. Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155773
Modern Language Association (MLA)
Kim, Bumjung…[et al.]. Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1155773
American Medical Association (AMA)
Kim, Bumjung& Jo, Cheolmin& Choi, Ho-Young& Lee, Kyungjin. Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155773