Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review
المؤلفون المشاركون
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
Melo, Fabiana C. S. A.
García, Estefanny Ruiz
Gutierrez, Eliana Alviárez
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-28
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
The hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide.
It occurs primarily as manifestation of other pathological processes, such as viral hepatitis, cirrhosis, and toxin exposure that affect directly the cellular process.
Studies were selected from PubMed and Scopus databases according to the PRISMA statement.
The research filters were constructed using three parameters: flavonoids, hepatocellular carcinoma, and animal model.
The bias analysis of the 34 selected works was done using the ARRIVE guidelines.
The most widely used flavonoid in the studies was epigallocatechin gallate extracted from green tea.
In general, the treatment with different flavonoids presented inhibition of tumor growth and antiangiogenic, antimetastatic, antioxidant, and anti-inflammatory activities.
The bias analysis evidenced the absence of methodological processes in all studies, such as the age or weight of the animals, the method of flavonoids’ extraction, or the experimental designs, analytical methods, and outcome measures.
It has been known that flavonoids have a protective effect against HCC.
However, the absence or incomplete characterization of the animal models, treatment protocols, and phytochemical and toxicity analyses impaired the internal validity of the individual studies, making it difficult to determine the effectiveness of plant-derived products in the treatment of HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
García, Estefanny Ruiz& Gutierrez, Eliana Alviárez& Melo, Fabiana C. S. A.& Novaes, Rômulo Dias& Gonçalves, Reggiani Vilela. 2018. Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1155843
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
García, Estefanny Ruiz…[et al.]. Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-23.
https://search.emarefa.net/detail/BIM-1155843
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
García, Estefanny Ruiz& Gutierrez, Eliana Alviárez& Melo, Fabiana C. S. A.& Novaes, Rômulo Dias& Gonçalves, Reggiani Vilela. Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1155843
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155843
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر