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Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review
Joint Authors
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
Melo, Fabiana C. S. A.
García, Estefanny Ruiz
Gutierrez, Eliana Alviárez
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide.
It occurs primarily as manifestation of other pathological processes, such as viral hepatitis, cirrhosis, and toxin exposure that affect directly the cellular process.
Studies were selected from PubMed and Scopus databases according to the PRISMA statement.
The research filters were constructed using three parameters: flavonoids, hepatocellular carcinoma, and animal model.
The bias analysis of the 34 selected works was done using the ARRIVE guidelines.
The most widely used flavonoid in the studies was epigallocatechin gallate extracted from green tea.
In general, the treatment with different flavonoids presented inhibition of tumor growth and antiangiogenic, antimetastatic, antioxidant, and anti-inflammatory activities.
The bias analysis evidenced the absence of methodological processes in all studies, such as the age or weight of the animals, the method of flavonoids’ extraction, or the experimental designs, analytical methods, and outcome measures.
It has been known that flavonoids have a protective effect against HCC.
However, the absence or incomplete characterization of the animal models, treatment protocols, and phytochemical and toxicity analyses impaired the internal validity of the individual studies, making it difficult to determine the effectiveness of plant-derived products in the treatment of HCC.
American Psychological Association (APA)
García, Estefanny Ruiz& Gutierrez, Eliana Alviárez& Melo, Fabiana C. S. A.& Novaes, Rômulo Dias& Gonçalves, Reggiani Vilela. 2018. Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1155843
Modern Language Association (MLA)
García, Estefanny Ruiz…[et al.]. Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-23.
https://search.emarefa.net/detail/BIM-1155843
American Medical Association (AMA)
García, Estefanny Ruiz& Gutierrez, Eliana Alviárez& Melo, Fabiana C. S. A.& Novaes, Rômulo Dias& Gonçalves, Reggiani Vilela. Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1155843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155843