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Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway
المؤلفون المشاركون
Gao, Jie
Luo, Songping
Wu, Hai-wang
Feng, Yi-hui
Wang, Dong-ying
Qiu, Wei-yu
Yu, Qing-ying
Yang, Li-lin
Liang, Chun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
For centuries, the Chinese herb Cuscuta chinensis has been applied clinically for abortion prevention in traditional Chinese medicine (TCM).
Total flavones extracted from Cuscuta chinensis (TFCC) are one of the active components in the herb and also display anti-abortion effect similar to the unprocessed material.
However, how TFCC exerts the anti-abortion effect remains largely unknown.
In this study, we aim at characterizing the anti-abortion effects of TFCC and its underlying molecular mechanism in vitro and in vivo using human primary decidua cells and a mifepristone-induced abortion model in rat, respectively.
The damage to the decidua caused by mifepristone in vivo was reversed by TFCC treatment in a dosage-dependent manner.
High dosage of TFCC significantly upregulated the expression of estrogen receptor (ER), progesterone receptor (PR), and prolactin receptor (PRLR) in decidua tissue but downregulated the expression of p-ERK.
Furthermore, we detected higher level of p-ERK and p-p38 in primary decidua cells from spontaneous abortion while treatment by TFCC downregulated their expression.
Our results suggest TFCC mediates its anti-abortion effect by interfering with MAPK signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Hai-wang& Feng, Yi-hui& Wang, Dong-ying& Qiu, Wei-yu& Yu, Qing-ying& Yang, Li-lin…[et al.]. 2018. Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155854
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Hai-wang…[et al.]. Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1155854
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Hai-wang& Feng, Yi-hui& Wang, Dong-ying& Qiu, Wei-yu& Yu, Qing-ying& Yang, Li-lin…[et al.]. Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155854
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155854
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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