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Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway
Joint Authors
Gao, Jie
Luo, Songping
Wu, Hai-wang
Feng, Yi-hui
Wang, Dong-ying
Qiu, Wei-yu
Yu, Qing-ying
Yang, Li-lin
Liang, Chun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
For centuries, the Chinese herb Cuscuta chinensis has been applied clinically for abortion prevention in traditional Chinese medicine (TCM).
Total flavones extracted from Cuscuta chinensis (TFCC) are one of the active components in the herb and also display anti-abortion effect similar to the unprocessed material.
However, how TFCC exerts the anti-abortion effect remains largely unknown.
In this study, we aim at characterizing the anti-abortion effects of TFCC and its underlying molecular mechanism in vitro and in vivo using human primary decidua cells and a mifepristone-induced abortion model in rat, respectively.
The damage to the decidua caused by mifepristone in vivo was reversed by TFCC treatment in a dosage-dependent manner.
High dosage of TFCC significantly upregulated the expression of estrogen receptor (ER), progesterone receptor (PR), and prolactin receptor (PRLR) in decidua tissue but downregulated the expression of p-ERK.
Furthermore, we detected higher level of p-ERK and p-p38 in primary decidua cells from spontaneous abortion while treatment by TFCC downregulated their expression.
Our results suggest TFCC mediates its anti-abortion effect by interfering with MAPK signaling pathway.
American Psychological Association (APA)
Wu, Hai-wang& Feng, Yi-hui& Wang, Dong-ying& Qiu, Wei-yu& Yu, Qing-ying& Yang, Li-lin…[et al.]. 2018. Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155854
Modern Language Association (MLA)
Wu, Hai-wang…[et al.]. Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1155854
American Medical Association (AMA)
Wu, Hai-wang& Feng, Yi-hui& Wang, Dong-ying& Qiu, Wei-yu& Yu, Qing-ying& Yang, Li-lin…[et al.]. Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1155854
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155854