Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells

المؤلفون المشاركون

Han, Ah-Reum
Han, Sujin
Lee, Yeon Jin
Kim, Jin-Baek
Seo, Eun Kyoung
Jung, Chan-Hun
Lee, Sanghun

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-09-24

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Radiotherapy using ionizing radiation is a major therapeutic modality for advanced human lung cancers.

However, ionizing radiation itself can induce malignant behaviors such as cancer cell migration and invasion, leading to local recurrence or distal metastasis.

Therefore, safer and more effective agents that inhibit the metastatic behaviors of cancer cells in radiotherapy are needed.

As a part of our ongoing search for new radiotherapy enhancers from medicinal herbs, we isolated the following triterpenoids from the ethanol extract of Centella asiatica: asiatic acid (1), madecassic acid (2), and asiaticoside (3).

These compounds inhibited the ionizing radiation-induced migration and invasion of A549 human lung cancer cells at noncytotoxic concentrations.

These results suggest that triterpenoids 1–3 isolated from C.

asiatica are candidate natural compounds to enhance the effect of radiotherapy in patients with non-small-cell lung cancer.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Han, Ah-Reum& Lee, Sanghun& Han, Sujin& Lee, Yeon Jin& Kim, Jin-Baek& Seo, Eun Kyoung…[et al.]. 2020. Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155870

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Han, Ah-Reum…[et al.]. Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1155870

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Han, Ah-Reum& Lee, Sanghun& Han, Sujin& Lee, Yeon Jin& Kim, Jin-Baek& Seo, Eun Kyoung…[et al.]. Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155870

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1155870