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Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells
Joint Authors
Han, Ah-Reum
Han, Sujin
Lee, Yeon Jin
Kim, Jin-Baek
Seo, Eun Kyoung
Jung, Chan-Hun
Lee, Sanghun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Radiotherapy using ionizing radiation is a major therapeutic modality for advanced human lung cancers.
However, ionizing radiation itself can induce malignant behaviors such as cancer cell migration and invasion, leading to local recurrence or distal metastasis.
Therefore, safer and more effective agents that inhibit the metastatic behaviors of cancer cells in radiotherapy are needed.
As a part of our ongoing search for new radiotherapy enhancers from medicinal herbs, we isolated the following triterpenoids from the ethanol extract of Centella asiatica: asiatic acid (1), madecassic acid (2), and asiaticoside (3).
These compounds inhibited the ionizing radiation-induced migration and invasion of A549 human lung cancer cells at noncytotoxic concentrations.
These results suggest that triterpenoids 1–3 isolated from C.
asiatica are candidate natural compounds to enhance the effect of radiotherapy in patients with non-small-cell lung cancer.
American Psychological Association (APA)
Han, Ah-Reum& Lee, Sanghun& Han, Sujin& Lee, Yeon Jin& Kim, Jin-Baek& Seo, Eun Kyoung…[et al.]. 2020. Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155870
Modern Language Association (MLA)
Han, Ah-Reum…[et al.]. Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1155870
American Medical Association (AMA)
Han, Ah-Reum& Lee, Sanghun& Han, Sujin& Lee, Yeon Jin& Kim, Jin-Baek& Seo, Eun Kyoung…[et al.]. Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155870