Sheng-Di-Da-Huang Decoction Inhibited Inflammation Expressed in Microglia after Intracerebral Hemorrhage in Rats
المؤلفون المشاركون
Cai, Min
Yu, Zhonghai
Zhang, Jingsi
Zhang, Wen
Xiang, Jun
Yang, Li
Zhang, Zhennian
Wu, Ting
Li, Xiangting
Fu, Maodong
Bao, Xuxia
Yu, Xiaofei
Cai, Dingfang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objects.
Sheng-Di-Da-Huang Decoction was used as an effective hemostatic agent in ancient China.
However, its therapeutic mechanism is still not clear.
Inflammatory injury plays a critical role in ICH-induced secondary brain injury.
After hemolysis, hematoma components are released, inducing microglial activation via TLR4, which initiates the activation of transcription factors (such as NF-κB) to regulate expression of proinflammatory cytokine genes.
This study aimed to verify the anti-inflammatory effects of Sheng-Di-Da-Huang Decoction on ICH rats.
Materials and Methods.
Intracerebral hemorrhage was induced by injection of bacterial collagenase (0.2 U) in rats.
Neurological deficits, brain water content, Evans blue extravasation, expression of TLR4, NF-κB, Iba-1 positive cells (activated microglia), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) were examined 1, 3, 7, and 14 days after collagenase injection.
MR images were also studied.
Results.
Sheng-Di-Da-Huang Decoction remarkably improved neurological function, reduced brain water content as well as Evans blue extravasation, downregulated expression of TLR4, NF-κB, TNF-α, and IL-1β, and inhibited microglial activation.
Conclusions.
Sheng-Di-Da-Huang Decoction reduced inflammation reaction after ICH through inhibited inflammation expressed in microglia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cai, Min& Yu, Zhonghai& Zhang, Wen& Yang, Li& Xiang, Jun& Zhang, Jingsi…[et al.]. 2018. Sheng-Di-Da-Huang Decoction Inhibited Inflammation Expressed in Microglia after Intracerebral Hemorrhage in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155897
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cai, Min…[et al.]. Sheng-Di-Da-Huang Decoction Inhibited Inflammation Expressed in Microglia after Intracerebral Hemorrhage in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155897
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cai, Min& Yu, Zhonghai& Zhang, Wen& Yang, Li& Xiang, Jun& Zhang, Jingsi…[et al.]. Sheng-Di-Da-Huang Decoction Inhibited Inflammation Expressed in Microglia after Intracerebral Hemorrhage in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155897
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155897
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر