Sheng-Di-Da-Huang Decoction Inhibited Inflammation Expressed in Microglia after Intracerebral Hemorrhage in Rats
Joint Authors
Cai, Min
Yu, Zhonghai
Zhang, Jingsi
Zhang, Wen
Xiang, Jun
Yang, Li
Zhang, Zhennian
Wu, Ting
Li, Xiangting
Fu, Maodong
Bao, Xuxia
Yu, Xiaofei
Cai, Dingfang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objects.
Sheng-Di-Da-Huang Decoction was used as an effective hemostatic agent in ancient China.
However, its therapeutic mechanism is still not clear.
Inflammatory injury plays a critical role in ICH-induced secondary brain injury.
After hemolysis, hematoma components are released, inducing microglial activation via TLR4, which initiates the activation of transcription factors (such as NF-κB) to regulate expression of proinflammatory cytokine genes.
This study aimed to verify the anti-inflammatory effects of Sheng-Di-Da-Huang Decoction on ICH rats.
Materials and Methods.
Intracerebral hemorrhage was induced by injection of bacterial collagenase (0.2 U) in rats.
Neurological deficits, brain water content, Evans blue extravasation, expression of TLR4, NF-κB, Iba-1 positive cells (activated microglia), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) were examined 1, 3, 7, and 14 days after collagenase injection.
MR images were also studied.
Results.
Sheng-Di-Da-Huang Decoction remarkably improved neurological function, reduced brain water content as well as Evans blue extravasation, downregulated expression of TLR4, NF-κB, TNF-α, and IL-1β, and inhibited microglial activation.
Conclusions.
Sheng-Di-Da-Huang Decoction reduced inflammation reaction after ICH through inhibited inflammation expressed in microglia.
American Psychological Association (APA)
Cai, Min& Yu, Zhonghai& Zhang, Wen& Yang, Li& Xiang, Jun& Zhang, Jingsi…[et al.]. 2018. Sheng-Di-Da-Huang Decoction Inhibited Inflammation Expressed in Microglia after Intracerebral Hemorrhage in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155897
Modern Language Association (MLA)
Cai, Min…[et al.]. Sheng-Di-Da-Huang Decoction Inhibited Inflammation Expressed in Microglia after Intracerebral Hemorrhage in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155897
American Medical Association (AMA)
Cai, Min& Yu, Zhonghai& Zhang, Wen& Yang, Li& Xiang, Jun& Zhang, Jingsi…[et al.]. Sheng-Di-Da-Huang Decoction Inhibited Inflammation Expressed in Microglia after Intracerebral Hemorrhage in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155897