Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLCQQQ-MSMS
المؤلفون المشاركون
Ma, Zengchun
Gao, Yue
Yang, Liang
Zhang, Zhaoyan
Wang, Yuguang
Huang, Guangyao
Li, Jian
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-09
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Objectives.
To investigate whether Panax ginseng (P.
ginseng) could affect the metabolism of Diester Alkaloids (DAs) derived from Aconiti Lateralis Radix in vivo.
Methods and Results.
24 male Sprague-Dawley rats were randomized for 7-day treatment with P.
ginseng (low, middle, and high), or vehicle.
Aconiti Lateralis Radix was administered orally to each group on the 8th day.
Plasma samples were collected, and Xevo TQ-S was used to detect the concentration of aconitine, mesaconitine, and hypaconitine in plasma.
We describe a fast and reproducible method to detect the concentration of aconitine, mesaconitine, and hypaconitine in plasma.
Compared to the control group, the AUC(0-t) of three DAs increased in both the middle and high dosing groups.
The Vz/F of three DAs in these groups as well as the CLz/F of aconitine in all P.
ginseng groups and the CLz/F of mesaconitine and hypaconitine in P.
ginseng middle and high groups were decreased compared to the control group.
Conclusion.
Orally administrated P.
ginseng potentially inhibits the metabolism of DAs from Aconiti Lateralis Radix in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Liang& Wang, Yuguang& Huang, Guangyao& Li, Jian& Zhang, Zhaoyan& Ma, Zengchun…[et al.]. 2018. Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLCQQQ-MSMS. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155925
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Liang…[et al.]. Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLCQQQ-MSMS. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1155925
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Liang& Wang, Yuguang& Huang, Guangyao& Li, Jian& Zhang, Zhaoyan& Ma, Zengchun…[et al.]. Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLCQQQ-MSMS. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155925
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155925
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر