Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLCQQQ-MSMS
Joint Authors
Ma, Zengchun
Gao, Yue
Yang, Liang
Zhang, Zhaoyan
Wang, Yuguang
Huang, Guangyao
Li, Jian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objectives.
To investigate whether Panax ginseng (P.
ginseng) could affect the metabolism of Diester Alkaloids (DAs) derived from Aconiti Lateralis Radix in vivo.
Methods and Results.
24 male Sprague-Dawley rats were randomized for 7-day treatment with P.
ginseng (low, middle, and high), or vehicle.
Aconiti Lateralis Radix was administered orally to each group on the 8th day.
Plasma samples were collected, and Xevo TQ-S was used to detect the concentration of aconitine, mesaconitine, and hypaconitine in plasma.
We describe a fast and reproducible method to detect the concentration of aconitine, mesaconitine, and hypaconitine in plasma.
Compared to the control group, the AUC(0-t) of three DAs increased in both the middle and high dosing groups.
The Vz/F of three DAs in these groups as well as the CLz/F of aconitine in all P.
ginseng groups and the CLz/F of mesaconitine and hypaconitine in P.
ginseng middle and high groups were decreased compared to the control group.
Conclusion.
Orally administrated P.
ginseng potentially inhibits the metabolism of DAs from Aconiti Lateralis Radix in rats.
American Psychological Association (APA)
Yang, Liang& Wang, Yuguang& Huang, Guangyao& Li, Jian& Zhang, Zhaoyan& Ma, Zengchun…[et al.]. 2018. Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLCQQQ-MSMS. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155925
Modern Language Association (MLA)
Yang, Liang…[et al.]. Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLCQQQ-MSMS. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1155925
American Medical Association (AMA)
Yang, Liang& Wang, Yuguang& Huang, Guangyao& Li, Jian& Zhang, Zhaoyan& Ma, Zengchun…[et al.]. Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLCQQQ-MSMS. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155925