Identification of Active Compounds of Mahuang Fuzi Xixin Decoction and Their Mechanisms of Action by LC-MSMS and Network Pharmacology

المؤلفون المشاركون

Tang, Qingfa
Liang, Xiao
Liu, Chang-Shun
Xia, Ting
Tan, Xiao-Mei

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-05-25

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري

الملخص EN

The decoction is an important dosage form of traditional Chinese medicine (TCM) administration.

The Mahuang Fuzi Xixin decoction (MFXD) is widely used to treat allergic rhinitis (AR) in China.

However, its active compounds and therapeutic mechanisms are unclear.

The aim of this study was to establish an integrative method to identify the bioactive compounds and reveal the mechanisms of action of MFXD.

LC-MS/MS was used to identify the compounds in MFXD, followed by screening for oral bioavailability.

TCMSP, BindingDB, STRING, DAVID, and KEGG databases and algorithms were used to gather information.

Cytoscape was used to visualize the networks.

Twenty-four bioactive compounds were identified, and thirty-seven predicted targets of these compounds were associated with AR.

DAVID analysis suggested that these compounds exert their therapeutic effects by modulating the Fc epsilon RI, B-cell receptor, Toll-like receptor, TNF, NF-κB, and T-cell receptor signaling pathways.

The PI3K/AKT and cAMP signaling pathways were also implicated.

Ten of the identified compounds, quercetin, pseudoephedrine, ephedrine, β-asarone, methylephedrine, α-linolenic acid, cathine, ferulic acid, nardosinone, and higenamine, seemed to account for most of the beneficial effects of MFXD in AR.

This study showed that LC-MS/MS followed by network pharmacology analysis is useful to elucidate the complex mechanisms of action of TCM formulas.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liang, Xiao& Liu, Chang-Shun& Xia, Ting& Tang, Qingfa& Tan, Xiao-Mei. 2020. Identification of Active Compounds of Mahuang Fuzi Xixin Decoction and Their Mechanisms of Action by LC-MSMS and Network Pharmacology. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155934

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liang, Xiao…[et al.]. Identification of Active Compounds of Mahuang Fuzi Xixin Decoction and Their Mechanisms of Action by LC-MSMS and Network Pharmacology. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1155934

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liang, Xiao& Liu, Chang-Shun& Xia, Ting& Tang, Qingfa& Tan, Xiao-Mei. Identification of Active Compounds of Mahuang Fuzi Xixin Decoction and Their Mechanisms of Action by LC-MSMS and Network Pharmacology. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155934

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1155934