Genotoxic and Chemopreventive Effects of Vochysia divergens Leaves (Pantanal, Brazil)
المؤلفون المشاركون
de Oliveira, Pollyanna Francielli
Mendes, Suzana Amorim
Acésio, Nathália Oliveira
Filho, Luis Claudio Kellner
Pimenta, Leticia Pereira
Siqueira, Kátia Aparecida
Soares, Marcos Antônio
Januário, Ana Helena
Tavares, Denise Crispim
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The medicinal plant Vochysia divergens is a colonizing tree species of the Pantanal, a unique and little explored wetland region in Brazil.
This species is used in folk medicine as syrups and teas to treat respiratory infections, digestive disorders, asthma, scarring, and skin diseases.
The objectives of this study were to evaluate the antioxidant, cytotoxic, and genotoxic potential of the ethanolic extract of Vochysia divergens leaves (VdE), as well as the influence of VdE and its major component (the flavone 3′,5-dimethoxy luteolin-7-O-β-glucopyranoside; 3′5 DL) on MMS-induced genotoxicity.
The extract significantly reduced the viability of V79 cells in the colorimetric XTT assay at concentrations ≥ 39 μg/mL.
A significant increase in micronucleus frequencies was observed in V79 cell cultures treated with VdE concentrations of 160 and 320 μg/mL.
However, animals treated with the tested doses of VdE (500, 1000, and 2000 mg/kg b.w.) exhibited frequencies that did not differ significantly from those of the negative control group, indicating the absence of genotoxicity.
The results also showed that VdE was effective in reducing MMS-induced genotoxicity at concentrations of 20, 40, and 80 μg/mL in the in vitro test system and at a dose of 15 mg/kg b.w.
in the in vivo test system.
Its major component 3′5 DL exerted no protective effect, suggesting that it is not responsible for the effect of the extract.
The results of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay showed that VdE was able to scavenge 92.6% of free radicals.
In conclusion, the results suggest that the protective effect of VdE may be related, at least in part, to the antioxidant activity of its chemical constituents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Oliveira, Pollyanna Francielli& Mendes, Suzana Amorim& Acésio, Nathália Oliveira& Filho, Luis Claudio Kellner& Pimenta, Leticia Pereira& Siqueira, Kátia Aparecida…[et al.]. 2018. Genotoxic and Chemopreventive Effects of Vochysia divergens Leaves (Pantanal, Brazil). Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1155960
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Oliveira, Pollyanna Francielli…[et al.]. Genotoxic and Chemopreventive Effects of Vochysia divergens Leaves (Pantanal, Brazil). Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1155960
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Oliveira, Pollyanna Francielli& Mendes, Suzana Amorim& Acésio, Nathália Oliveira& Filho, Luis Claudio Kellner& Pimenta, Leticia Pereira& Siqueira, Kátia Aparecida…[et al.]. Genotoxic and Chemopreventive Effects of Vochysia divergens Leaves (Pantanal, Brazil). Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1155960
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155960
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر