Antimicrobial, Cytotoxic, and Antioxidant Potential of a Novel Flavone “6,7,4′-Trimethyl Flavone” Isolated from Wulfenia amherstiana
المؤلفون المشاركون
Kakar, Maria
Amin, Muhammad Usman
Alghamdi, Saad
Sahibzada, Muhammad Umar Khayam
Ahmad, Nisar
Ullah, Naseem
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Wulfenia amherstiana belongs to the Scrophulariaceae family and various plants of this family are known for their biological activities.
The present study was focused on the isolation of bioactive compounds including a novel flavone 6,7,4′-trimethyl flavone (TMF) along with three known flavonoids such as quercetin, rutin, and a steroid β-sitosterol which were isolated from the ethanolic extract of W.
amherstiana (Himalayan Wulfenia) through column chromatography and purified by using HPLC.
Their structures were identified and elucidated through electron ionization mass spectroscopy (EIMS), 1DNMR (1H-NMR and 13C-NMR), and 2DNMR (COSY, HMQC, and HMBC) spectroscopy.
The antimicrobial activities of this novel compound were evaluated through agar well diffusion method, while antioxidant and cytotoxic activities were assessed through 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging assay and brine shrimp lethality assay, respectively.
The NMR data revealed that TMF is a novel compound.
TMF showed potential antibacterial and antifungal activities against Staphylococcus aureus (MIC = 128 μg/ml) and Candida albicans (MIC = 128 μg/ml).
The cytotoxic potential of TMF was determined from brine shrimp lethality assay with LD50 of 127.01 μg/ml.
The free-radical scavenging potential of TMF at various concentrations implicated its strong antioxidant activity in vitro.
The results revealed that TMF demonstrated substantial antimicrobial activity against S.
aureus and C.
albicans, strong antioxidant activity, and moderately cytotoxic activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kakar, Maria& Amin, Muhammad Usman& Alghamdi, Saad& Sahibzada, Muhammad Umar Khayam& Ahmad, Nisar& Ullah, Naseem. 2020. Antimicrobial, Cytotoxic, and Antioxidant Potential of a Novel Flavone “6,7,4′-Trimethyl Flavone” Isolated from Wulfenia amherstiana. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155984
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kakar, Maria…[et al.]. Antimicrobial, Cytotoxic, and Antioxidant Potential of a Novel Flavone “6,7,4′-Trimethyl Flavone” Isolated from Wulfenia amherstiana. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1155984
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kakar, Maria& Amin, Muhammad Usman& Alghamdi, Saad& Sahibzada, Muhammad Umar Khayam& Ahmad, Nisar& Ullah, Naseem. Antimicrobial, Cytotoxic, and Antioxidant Potential of a Novel Flavone “6,7,4′-Trimethyl Flavone” Isolated from Wulfenia amherstiana. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155984
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155984
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر