Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MSMS: Application to Comparative Pharmacokinetic and Brain Distribution Studies
المؤلفون المشاركون
Li, Bo
Chen, Su-Hong
Lei, Shan-Shan
Lu, Min
Jin, Lei
Zheng, Maoen
Sun, Peilu
Xiong, Shan
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Brigatinib and brigatinib-analog are potent and selective ALK inhibitors with the similar structure.
A simple and sensitive high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of brigatinib and brigatinib-analog in rat plasma and brain homogenate was developed and validated.
Chromatographic separation was carried out on an ODS column with acetonitrile and 0.1% formic acid in water as the mobile phase with gradient elution at a flow rate of 0.5 mL/min.
Detections were performed using a TSQ Quantum Ultra mass spectrometric detector with electrospray ionization (ESI) interface, which was operated in the positive ion mode.
A simple protein precipitation preparation process was used.
The lower limits of quantification (LLOQs) were 1.0 ng/mL and 0.5 ng/mL for analytes in rat plasma and brain homogenate, respectively.
The intrabatch and interbatch precision and accuracy of brigatinib and brigatinib-analog were well within the acceptable limits of variation.
The simple and sensitive LC-MS/MS method was successfully applied to the pharmacokinetic and brain distribution studies following a single oral administration of brigatinib and brigatinib-analog to rats.
The above studies would lay a good foundation for the further applications of brigatinib and brigatinib-analog.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Bo& Lu, Min& Jin, Lei& Zheng, Maoen& Sun, Peilu& Lei, Shan-Shan…[et al.]. 2019. Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MSMS: Application to Comparative Pharmacokinetic and Brain Distribution Studies. International Journal of Analytical Chemistry،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1156003
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Bo…[et al.]. Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MSMS: Application to Comparative Pharmacokinetic and Brain Distribution Studies. International Journal of Analytical Chemistry No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1156003
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Bo& Lu, Min& Jin, Lei& Zheng, Maoen& Sun, Peilu& Lei, Shan-Shan…[et al.]. Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MSMS: Application to Comparative Pharmacokinetic and Brain Distribution Studies. International Journal of Analytical Chemistry. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1156003
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156003
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر