Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models
المؤلفون المشاركون
Jia, Renyong
Yang, Yi
Song, Xu
Zou, Yuanfeng
Li, Lixia
Yin, Lizi
He, Changliang
Liang, Xiaoxia
Yue, Guizhou
Yin, Zhongqiong
Sun, Kai
Cui, Qiankun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
Pain and inflammation are associated with many diseases in humans and animals.
Galla Chinensis, a traditional Chinese medicine, has a variety of pharmacological properties.
The purpose of this study was to evaluate analgesic and anti-inflammatory activities of Galla Chinensis through different animal models.
Method.
The analgesic activities were evaluated by hot-plate and writhing tests.
The anti-inflammatory effects were assessed by ear edema, capillary permeability, and paw edema tests.
The contents of cytokines (NO, iNOS, PGE2, and IL-10) in serum of rats in paw edema test were inspected by ELISA assays.
Results.
In the hot-plate test, Galla Chinensis could significantly extend pain threshold when compared to control group.
The inhibitory rates of writhes ranged from 36.62% to 68.57% in Galla Chinensis-treated mice.
Treatment with Galla Chinensis (1 and 0.5 g/kg) could significantly inhibit ear edema (47.45 and 36.91%, resp.; P < 0.01).
Galla Chinensis (1 g/kg) had significant (P < 0.05) anti-inflammatory activity in capillary permeability test (29.04%).
In carrageenan-induced edema test, the inhibitory rates were 43.71% and 44.07% (P < 0.01) at 1 h and 2 h after administration of Galla Chinensis (1 g/kg), respectively, and the levels of proinflammatory cytokines were significantly reduced.
Conclusion.
These results suggest that Galla Chinensis has analgesic and anti-inflammatory effects, which may be a candidate drug for the treatment of inflammation and pain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Kai& Song, Xu& Jia, Renyong& Yin, Zhongqiong& Zou, Yuanfeng& Li, Lixia…[et al.]. 2018. Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1156021
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Kai…[et al.]. Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1156021
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Kai& Song, Xu& Jia, Renyong& Yin, Zhongqiong& Zou, Yuanfeng& Li, Lixia…[et al.]. Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1156021
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156021
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر