Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models
Joint Authors
Jia, Renyong
Yang, Yi
Song, Xu
Zou, Yuanfeng
Li, Lixia
Yin, Lizi
He, Changliang
Liang, Xiaoxia
Yue, Guizhou
Yin, Zhongqiong
Sun, Kai
Cui, Qiankun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
Pain and inflammation are associated with many diseases in humans and animals.
Galla Chinensis, a traditional Chinese medicine, has a variety of pharmacological properties.
The purpose of this study was to evaluate analgesic and anti-inflammatory activities of Galla Chinensis through different animal models.
Method.
The analgesic activities were evaluated by hot-plate and writhing tests.
The anti-inflammatory effects were assessed by ear edema, capillary permeability, and paw edema tests.
The contents of cytokines (NO, iNOS, PGE2, and IL-10) in serum of rats in paw edema test were inspected by ELISA assays.
Results.
In the hot-plate test, Galla Chinensis could significantly extend pain threshold when compared to control group.
The inhibitory rates of writhes ranged from 36.62% to 68.57% in Galla Chinensis-treated mice.
Treatment with Galla Chinensis (1 and 0.5 g/kg) could significantly inhibit ear edema (47.45 and 36.91%, resp.; P < 0.01).
Galla Chinensis (1 g/kg) had significant (P < 0.05) anti-inflammatory activity in capillary permeability test (29.04%).
In carrageenan-induced edema test, the inhibitory rates were 43.71% and 44.07% (P < 0.01) at 1 h and 2 h after administration of Galla Chinensis (1 g/kg), respectively, and the levels of proinflammatory cytokines were significantly reduced.
Conclusion.
These results suggest that Galla Chinensis has analgesic and anti-inflammatory effects, which may be a candidate drug for the treatment of inflammation and pain.
American Psychological Association (APA)
Sun, Kai& Song, Xu& Jia, Renyong& Yin, Zhongqiong& Zou, Yuanfeng& Li, Lixia…[et al.]. 2018. Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1156021
Modern Language Association (MLA)
Sun, Kai…[et al.]. Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1156021
American Medical Association (AMA)
Sun, Kai& Song, Xu& Jia, Renyong& Yin, Zhongqiong& Zou, Yuanfeng& Li, Lixia…[et al.]. Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Galla Chinensis In Vivo Models. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1156021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156021