Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models
المؤلفون المشاركون
Kukuia, Kennedy Kwami Edem
N’guessan, Benoit Banga
Amoateng, Patrick
Mensah, Jeffrey Amoako
Amponsah, Seth Kwabena
Asiedu-Gyekye, Isaac Julius
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Trichilia monadelpha is a common medicinal plant used traditionally in treating central nervous system conditions such as epilepsy, depression, pain, and psychosis.
In this study, the antidepressant-like effect of crude extracts of the stem bark of T.
monadelpha was investigated using two classical murine models, forced swimming test (FST) and tail suspension test (TST).
The extracts, petroleum ether, ethyl acetate, and hydroethanolic extracts (30–300 mg/kg, p.o.), standard drug (imipramine; fluoxetine, 3–30 mg/kg, p.o.), and saline (vehicle) were given to mice one hour prior to the acute study.
In a separate experiment the components (flavonoids, saponins, alkaloids, tannins, and terpenoids; 30–300 mg/kg, p.o.) from the most efficacious extract fraction were screened to ascertain which components possessed the antidepressant effect.
All the extracts and components significantly induced a decline in immobility in the FST and TST, indicative of an antidepressant-like activity.
The extracts and some components showed increase in swimming and climbing in the FST as well as a significant enhancement in swinging and/or curling scores in the TST, suggesting a possible involvement of monoaminergic and/or opioidergic activity.
This study reveals the antidepressant-like potential of the stem bark extracts and components of T.
monadelpha.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kukuia, Kennedy Kwami Edem& Mensah, Jeffrey Amoako& Amoateng, Patrick& Amponsah, Seth Kwabena& N’guessan, Benoit Banga& Asiedu-Gyekye, Isaac Julius. 2018. Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156057
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kukuia, Kennedy Kwami Edem…[et al.]. Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156057
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kukuia, Kennedy Kwami Edem& Mensah, Jeffrey Amoako& Amoateng, Patrick& Amponsah, Seth Kwabena& N’guessan, Benoit Banga& Asiedu-Gyekye, Isaac Julius. Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156057
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156057
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر