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Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models
Joint Authors
Kukuia, Kennedy Kwami Edem
N’guessan, Benoit Banga
Amoateng, Patrick
Mensah, Jeffrey Amoako
Amponsah, Seth Kwabena
Asiedu-Gyekye, Isaac Julius
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Trichilia monadelpha is a common medicinal plant used traditionally in treating central nervous system conditions such as epilepsy, depression, pain, and psychosis.
In this study, the antidepressant-like effect of crude extracts of the stem bark of T.
monadelpha was investigated using two classical murine models, forced swimming test (FST) and tail suspension test (TST).
The extracts, petroleum ether, ethyl acetate, and hydroethanolic extracts (30–300 mg/kg, p.o.), standard drug (imipramine; fluoxetine, 3–30 mg/kg, p.o.), and saline (vehicle) were given to mice one hour prior to the acute study.
In a separate experiment the components (flavonoids, saponins, alkaloids, tannins, and terpenoids; 30–300 mg/kg, p.o.) from the most efficacious extract fraction were screened to ascertain which components possessed the antidepressant effect.
All the extracts and components significantly induced a decline in immobility in the FST and TST, indicative of an antidepressant-like activity.
The extracts and some components showed increase in swimming and climbing in the FST as well as a significant enhancement in swinging and/or curling scores in the TST, suggesting a possible involvement of monoaminergic and/or opioidergic activity.
This study reveals the antidepressant-like potential of the stem bark extracts and components of T.
monadelpha.
American Psychological Association (APA)
Kukuia, Kennedy Kwami Edem& Mensah, Jeffrey Amoako& Amoateng, Patrick& Amponsah, Seth Kwabena& N’guessan, Benoit Banga& Asiedu-Gyekye, Isaac Julius. 2018. Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156057
Modern Language Association (MLA)
Kukuia, Kennedy Kwami Edem…[et al.]. Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156057
American Medical Association (AMA)
Kukuia, Kennedy Kwami Edem& Mensah, Jeffrey Amoako& Amoateng, Patrick& Amponsah, Seth Kwabena& N’guessan, Benoit Banga& Asiedu-Gyekye, Isaac Julius. Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156057