A Network Pharmacology Approach to Uncover the Mechanisms of Shen-Qi-Di-Huang Decoction against Diabetic Nephropathy
المؤلفون المشاركون
Zhao, Linhua
Tong, Xiaolin
Di, Sha
Han, Lin
Wang, Qing
Yang, Yingying
Liu, Xinkui
Li, Fan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-01
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Shen-Qi-Di-Huang decoction (SQDHD), a well-known herbal formula from China, has been widely used in the treatment of diabetic nephropathy (DN).
However, the pharmacological mechanisms of SQDHD have not been entirely elucidated.
At first, we conducted a comprehensive literature search to identify the active constituents of SQDHD, determined their corresponding targets, and obtained known DN targets from several databases.
A protein-protein interaction network was then built to explore the complex relations between SQDHD targets and those known to treat DN.
Following the topological feature screening of each node in the network, 400 major targets of SQDHD were obtained.
The pathway enrichment analysis results acquired from DAVID showed that the significant bioprocesses and pathways include oxidative stress, response to glucose, regulation of blood pressure, regulation of cell proliferation, cytokine-mediated signaling pathway, and the apoptotic signaling pathway.
More interestingly, five key targets of SQDHD, named AKT1, AR, CTNNB1, EGFR, and ESR1, were significant in the regulation of the above bioprocesses and pathways.
This study partially verified and predicted the pharmacological and molecular mechanisms of SQDHD on DN from a holistic perspective.
This has laid the foundation for further experimental research and has expanded the rational application of SQDHD in clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Di, Sha& Han, Lin& Wang, Qing& Liu, Xinkui& Yang, Yingying& Li, Fan…[et al.]. 2018. A Network Pharmacology Approach to Uncover the Mechanisms of Shen-Qi-Di-Huang Decoction against Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156079
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Di, Sha…[et al.]. A Network Pharmacology Approach to Uncover the Mechanisms of Shen-Qi-Di-Huang Decoction against Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1156079
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Di, Sha& Han, Lin& Wang, Qing& Liu, Xinkui& Yang, Yingying& Li, Fan…[et al.]. A Network Pharmacology Approach to Uncover the Mechanisms of Shen-Qi-Di-Huang Decoction against Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156079
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156079
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر