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A Network Pharmacology Approach to Uncover the Mechanisms of Shen-Qi-Di-Huang Decoction against Diabetic Nephropathy
Joint Authors
Zhao, Linhua
Tong, Xiaolin
Di, Sha
Han, Lin
Wang, Qing
Yang, Yingying
Liu, Xinkui
Li, Fan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Shen-Qi-Di-Huang decoction (SQDHD), a well-known herbal formula from China, has been widely used in the treatment of diabetic nephropathy (DN).
However, the pharmacological mechanisms of SQDHD have not been entirely elucidated.
At first, we conducted a comprehensive literature search to identify the active constituents of SQDHD, determined their corresponding targets, and obtained known DN targets from several databases.
A protein-protein interaction network was then built to explore the complex relations between SQDHD targets and those known to treat DN.
Following the topological feature screening of each node in the network, 400 major targets of SQDHD were obtained.
The pathway enrichment analysis results acquired from DAVID showed that the significant bioprocesses and pathways include oxidative stress, response to glucose, regulation of blood pressure, regulation of cell proliferation, cytokine-mediated signaling pathway, and the apoptotic signaling pathway.
More interestingly, five key targets of SQDHD, named AKT1, AR, CTNNB1, EGFR, and ESR1, were significant in the regulation of the above bioprocesses and pathways.
This study partially verified and predicted the pharmacological and molecular mechanisms of SQDHD on DN from a holistic perspective.
This has laid the foundation for further experimental research and has expanded the rational application of SQDHD in clinical practice.
American Psychological Association (APA)
Di, Sha& Han, Lin& Wang, Qing& Liu, Xinkui& Yang, Yingying& Li, Fan…[et al.]. 2018. A Network Pharmacology Approach to Uncover the Mechanisms of Shen-Qi-Di-Huang Decoction against Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156079
Modern Language Association (MLA)
Di, Sha…[et al.]. A Network Pharmacology Approach to Uncover the Mechanisms of Shen-Qi-Di-Huang Decoction against Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1156079
American Medical Association (AMA)
Di, Sha& Han, Lin& Wang, Qing& Liu, Xinkui& Yang, Yingying& Li, Fan…[et al.]. A Network Pharmacology Approach to Uncover the Mechanisms of Shen-Qi-Di-Huang Decoction against Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1156079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156079