Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome

المؤلفون المشاركون

Yuan, Mengqian
Xu, Wanli
Wu, Xiaoliang
Geng, Hao
Chen, Lu
Zhou, Junling
Song, Yafang
Pei, Lixia
Sun, Jianhua

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-10-18

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

The role of protease-activated receptor 2 (PAR2) in the analgesic effect of electroacupuncture (EA) on visceral hypersensitivity (VH) in postinfectious irritable bowel syndrome (PI-IBS) has yet to be elucidated.

Aim.

In this study, we investigated the molecular mechanisms underlying the analgesic effect of EA in a rat model of PI-IBS.

Methods.

Visceral hypersensitivity was evaluated by the abdominal withdrawal reflex test before and after administration of the PAR2 agonist, PAR2-AP, and/or EA.

The protein expression and mRNA levels of PAR2, CGRP, SP, and TPSP in colon tissues were measured by immunofluorescence, western blot, and RT-PCR.

Results.

We found that EA could alleviate VH and significantly decrease protein and mRNA levels of PAR2, TPSP, CGRP, and SP in PI-IBS rats.

The analgesic effect of EA on VH was slightly reduced in the presence of PAR2-AP.

Conclusions.

These results suggest that EA alleviates VH symptoms through downregulation of the levels of the TPSP/PAR2/SP/CGRP signaling axis in colon tissues in PI-IBS rats.

Together, our data suggests that PAR2 plays a critical role in the analgesic effect of EA on VH in PI-IBS.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xu, Wanli& Yuan, Mengqian& Wu, Xiaoliang& Geng, Hao& Chen, Lu& Zhou, Junling…[et al.]. 2018. Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156086

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xu, Wanli…[et al.]. Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156086

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xu, Wanli& Yuan, Mengqian& Wu, Xiaoliang& Geng, Hao& Chen, Lu& Zhou, Junling…[et al.]. Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156086

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1156086