Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome
Joint Authors
Yuan, Mengqian
Xu, Wanli
Wu, Xiaoliang
Geng, Hao
Chen, Lu
Zhou, Junling
Song, Yafang
Pei, Lixia
Sun, Jianhua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The role of protease-activated receptor 2 (PAR2) in the analgesic effect of electroacupuncture (EA) on visceral hypersensitivity (VH) in postinfectious irritable bowel syndrome (PI-IBS) has yet to be elucidated.
Aim.
In this study, we investigated the molecular mechanisms underlying the analgesic effect of EA in a rat model of PI-IBS.
Methods.
Visceral hypersensitivity was evaluated by the abdominal withdrawal reflex test before and after administration of the PAR2 agonist, PAR2-AP, and/or EA.
The protein expression and mRNA levels of PAR2, CGRP, SP, and TPSP in colon tissues were measured by immunofluorescence, western blot, and RT-PCR.
Results.
We found that EA could alleviate VH and significantly decrease protein and mRNA levels of PAR2, TPSP, CGRP, and SP in PI-IBS rats.
The analgesic effect of EA on VH was slightly reduced in the presence of PAR2-AP.
Conclusions.
These results suggest that EA alleviates VH symptoms through downregulation of the levels of the TPSP/PAR2/SP/CGRP signaling axis in colon tissues in PI-IBS rats.
Together, our data suggests that PAR2 plays a critical role in the analgesic effect of EA on VH in PI-IBS.
American Psychological Association (APA)
Xu, Wanli& Yuan, Mengqian& Wu, Xiaoliang& Geng, Hao& Chen, Lu& Zhou, Junling…[et al.]. 2018. Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156086
Modern Language Association (MLA)
Xu, Wanli…[et al.]. Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156086
American Medical Association (AMA)
Xu, Wanli& Yuan, Mengqian& Wu, Xiaoliang& Geng, Hao& Chen, Lu& Zhou, Junling…[et al.]. Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156086