Effects of Modified Sanzi Yangqin Decoction on Tyrosine Phosphorylation of IRS-1 in Skeletal Muscle of Type 2 Diabetic Rats
المؤلفون المشاركون
Jian, Li
Tian, Chunyu
La, Xiaojin
Wang, Ya
Dong, Yushan
Qi, Feng
Qiu, Changlong
Gao, Xiujuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study aimed to investigate the effect of Modified Sanzi Yangqin Decoction on tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1) in skeletal muscle of type 2 diabetic rats.
The rat model of type 2 diabetes was induced by high-fat diet and multiple low-dose streptozotocin injections.
Diabetic model rats were randomly divided into 5 groups: the model control group, the metformin group, and Modified Sanzi Yangqin Decoction groups of low, medium, and high doses.
OGTT was conducted every two weeks during treatment period.
At the end of the treatment, the fasting blood glucose (FBG) level and the fasting C-peptide level were measured to calculate insulin resistance index.
The levels of IRS-1, p-IRS-1Tyr895, and protein tyrosine phosphates 1B (PTP1B) in skeletal muscle were also measured.
Modified Sanzi Yangqin Decoction significantly reduced the FBG level, increased the fasting C-peptide level, and lowered the insulin resistance index in type 2 diabetic rats.
It also significantly increased the protein level of p-IRS-1Tyr895 and reduced the PTP1B protein level in skeletal muscle of type 2 diabetic rats.
Modified Sanzi Yangqin Decoction increases tyrosine phosphorylation of IRS-1 in skeletal muscle of type 2 diabetic rats, which results from the increase of p-IRS-1Tyr895 protein and is related to the suppression of PTP1B protein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ya& La, Xiaojin& Tian, Chunyu& Dong, Yushan& Qi, Feng& Qiu, Changlong…[et al.]. 2018. Effects of Modified Sanzi Yangqin Decoction on Tyrosine Phosphorylation of IRS-1 in Skeletal Muscle of Type 2 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156092
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ya…[et al.]. Effects of Modified Sanzi Yangqin Decoction on Tyrosine Phosphorylation of IRS-1 in Skeletal Muscle of Type 2 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156092
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ya& La, Xiaojin& Tian, Chunyu& Dong, Yushan& Qi, Feng& Qiu, Changlong…[et al.]. Effects of Modified Sanzi Yangqin Decoction on Tyrosine Phosphorylation of IRS-1 in Skeletal Muscle of Type 2 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156092
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156092
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر