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Effects of Modified Sanzi Yangqin Decoction on Tyrosine Phosphorylation of IRS-1 in Skeletal Muscle of Type 2 Diabetic Rats
Joint Authors
Jian, Li
Tian, Chunyu
La, Xiaojin
Wang, Ya
Dong, Yushan
Qi, Feng
Qiu, Changlong
Gao, Xiujuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study aimed to investigate the effect of Modified Sanzi Yangqin Decoction on tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1) in skeletal muscle of type 2 diabetic rats.
The rat model of type 2 diabetes was induced by high-fat diet and multiple low-dose streptozotocin injections.
Diabetic model rats were randomly divided into 5 groups: the model control group, the metformin group, and Modified Sanzi Yangqin Decoction groups of low, medium, and high doses.
OGTT was conducted every two weeks during treatment period.
At the end of the treatment, the fasting blood glucose (FBG) level and the fasting C-peptide level were measured to calculate insulin resistance index.
The levels of IRS-1, p-IRS-1Tyr895, and protein tyrosine phosphates 1B (PTP1B) in skeletal muscle were also measured.
Modified Sanzi Yangqin Decoction significantly reduced the FBG level, increased the fasting C-peptide level, and lowered the insulin resistance index in type 2 diabetic rats.
It also significantly increased the protein level of p-IRS-1Tyr895 and reduced the PTP1B protein level in skeletal muscle of type 2 diabetic rats.
Modified Sanzi Yangqin Decoction increases tyrosine phosphorylation of IRS-1 in skeletal muscle of type 2 diabetic rats, which results from the increase of p-IRS-1Tyr895 protein and is related to the suppression of PTP1B protein.
American Psychological Association (APA)
Wang, Ya& La, Xiaojin& Tian, Chunyu& Dong, Yushan& Qi, Feng& Qiu, Changlong…[et al.]. 2018. Effects of Modified Sanzi Yangqin Decoction on Tyrosine Phosphorylation of IRS-1 in Skeletal Muscle of Type 2 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156092
Modern Language Association (MLA)
Wang, Ya…[et al.]. Effects of Modified Sanzi Yangqin Decoction on Tyrosine Phosphorylation of IRS-1 in Skeletal Muscle of Type 2 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156092
American Medical Association (AMA)
Wang, Ya& La, Xiaojin& Tian, Chunyu& Dong, Yushan& Qi, Feng& Qiu, Changlong…[et al.]. Effects of Modified Sanzi Yangqin Decoction on Tyrosine Phosphorylation of IRS-1 in Skeletal Muscle of Type 2 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156092