Electroacupuncture Ameliorates Acute Myocardial Ischemia: A Potential Role of the Locus Coeruleus
المؤلفون المشاركون
Zhou, Meiqi
Wu, Shengbing
Zhu, Guoqi
Wu, Xin
Wang, Kun
Cui, Shuai
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The locus coeruleus (LC) is closely linked with cardiovascular disease.
However, whether it mediates the alleviating effect of electroacupuncture (EA) on acute myocardial ischemia (AMI) remains unclear.
A rat model of myocardial ischemia was established through occlusion of the left anterior descending coronary artery.
Multichannel in vivo recording and other techniques were used to assess neurons in the LC, norepinephrine (NE) and dopamine (DA) levels in central and myocardial tissue, serum levels of inflammatory factors, and cardiac function.
After induction of AMI, LC neuron activity increased and the central NE concentrations increased, while those of DA decreased.
Moreover, the serum levels of high-sensitivity C-reactive protein (hs-CRP) increased, whereas those of interleukin-10 (IL-10) decreased.
However, these effects were reversed by EA.
Additionally, LC lesioning affected NE and DA levels in myocardial tissue and weakened the antimyocardial ischemic effect of EA.
Collectively, our results indicated that LC is closely related to AMI and plays an important role in the antimyocardial ischemic effect of EA.
This mechanism may be related to inhibition of LC neuron activity by EA, which inhibits the release of large amounts of hs-CRP and promotes that of IL-10 in the serum.
Besides, after LC lesioning, EA may improve cardiac function by inhibiting the release of large amounts of NE and promoting the release of DA in myocardial tissue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Xin& Wang, Kun& Cui, Shuai& Wu, Shengbing& Zhu, Guoqi& Zhou, Meiqi. 2020. Electroacupuncture Ameliorates Acute Myocardial Ischemia: A Potential Role of the Locus Coeruleus. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156093
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Xin…[et al.]. Electroacupuncture Ameliorates Acute Myocardial Ischemia: A Potential Role of the Locus Coeruleus. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1156093
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Xin& Wang, Kun& Cui, Shuai& Wu, Shengbing& Zhu, Guoqi& Zhou, Meiqi. Electroacupuncture Ameliorates Acute Myocardial Ischemia: A Potential Role of the Locus Coeruleus. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156093
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156093
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر