Electroacupuncture Ameliorates Acute Myocardial Ischemia: A Potential Role of the Locus Coeruleus
Joint Authors
Zhou, Meiqi
Wu, Shengbing
Zhu, Guoqi
Wu, Xin
Wang, Kun
Cui, Shuai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The locus coeruleus (LC) is closely linked with cardiovascular disease.
However, whether it mediates the alleviating effect of electroacupuncture (EA) on acute myocardial ischemia (AMI) remains unclear.
A rat model of myocardial ischemia was established through occlusion of the left anterior descending coronary artery.
Multichannel in vivo recording and other techniques were used to assess neurons in the LC, norepinephrine (NE) and dopamine (DA) levels in central and myocardial tissue, serum levels of inflammatory factors, and cardiac function.
After induction of AMI, LC neuron activity increased and the central NE concentrations increased, while those of DA decreased.
Moreover, the serum levels of high-sensitivity C-reactive protein (hs-CRP) increased, whereas those of interleukin-10 (IL-10) decreased.
However, these effects were reversed by EA.
Additionally, LC lesioning affected NE and DA levels in myocardial tissue and weakened the antimyocardial ischemic effect of EA.
Collectively, our results indicated that LC is closely related to AMI and plays an important role in the antimyocardial ischemic effect of EA.
This mechanism may be related to inhibition of LC neuron activity by EA, which inhibits the release of large amounts of hs-CRP and promotes that of IL-10 in the serum.
Besides, after LC lesioning, EA may improve cardiac function by inhibiting the release of large amounts of NE and promoting the release of DA in myocardial tissue.
American Psychological Association (APA)
Wu, Xin& Wang, Kun& Cui, Shuai& Wu, Shengbing& Zhu, Guoqi& Zhou, Meiqi. 2020. Electroacupuncture Ameliorates Acute Myocardial Ischemia: A Potential Role of the Locus Coeruleus. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156093
Modern Language Association (MLA)
Wu, Xin…[et al.]. Electroacupuncture Ameliorates Acute Myocardial Ischemia: A Potential Role of the Locus Coeruleus. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1156093
American Medical Association (AMA)
Wu, Xin& Wang, Kun& Cui, Shuai& Wu, Shengbing& Zhu, Guoqi& Zhou, Meiqi. Electroacupuncture Ameliorates Acute Myocardial Ischemia: A Potential Role of the Locus Coeruleus. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156093