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Functional Bowel Disorders Are Associated with a Central Immune Activation
المؤلفون المشاركون
Farup, Per G.
Rudi, Knut
Lydersen, Stian
Hestad, Knut
Ueland, Thor
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication.
This study explored associations between functional gastrointestinal disorders (FGID) and inflammatory markers in subjects with these disorders.
Methods.
The FGID, including irritable bowel syndrome (IBS), were classified according to the Rome III criteria, and degree of symptoms was assessed with IBS symptom severity score (IBS-SSS).
A range of interleukins (IL), chemokines and growth factors, tryptophan, and kynurenine were analysed in serum and the cerebrospinal fluid (CSF), and short-chain fatty acids (SCFA) were analysed in the faeces.
The results are reported as partial correlation (pc) and p values.
Results.
Sixty-six subjects were included.
IBS was associated with high levels of tryptophan (p=0.048) and kynurenine (p=0.019) and low level of IL-10 (p=0.047) in the CSF.
IBS-SSS was associated with high tumor necrosis factor and low IL-10 in the CSF; pc=0.341 and p=0.009 and pc=−0.299 and p=0.023, respectively.
Propionic minus butyric acid in faeces was negatively associated with IL-10 in the CSF (pc=−0.416, p=0.005).
Conclusions.
FGID were associated with a proinflammatory immune activation in the central nervous system and a disturbed tryptophan metabolism that could have been mediated by the faecal microbiota.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Farup, Per G.& Ueland, Thor& Rudi, Knut& Lydersen, Stian& Hestad, Knut. 2017. Functional Bowel Disorders Are Associated with a Central Immune Activation. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156164
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Farup, Per G.…[et al.]. Functional Bowel Disorders Are Associated with a Central Immune Activation. Gastroenterology Research and Practice No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1156164
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Farup, Per G.& Ueland, Thor& Rudi, Knut& Lydersen, Stian& Hestad, Knut. Functional Bowel Disorders Are Associated with a Central Immune Activation. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156164
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156164
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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