Functional Bowel Disorders Are Associated with a Central Immune Activation
Joint Authors
Farup, Per G.
Rudi, Knut
Lydersen, Stian
Hestad, Knut
Ueland, Thor
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication.
This study explored associations between functional gastrointestinal disorders (FGID) and inflammatory markers in subjects with these disorders.
Methods.
The FGID, including irritable bowel syndrome (IBS), were classified according to the Rome III criteria, and degree of symptoms was assessed with IBS symptom severity score (IBS-SSS).
A range of interleukins (IL), chemokines and growth factors, tryptophan, and kynurenine were analysed in serum and the cerebrospinal fluid (CSF), and short-chain fatty acids (SCFA) were analysed in the faeces.
The results are reported as partial correlation (pc) and p values.
Results.
Sixty-six subjects were included.
IBS was associated with high levels of tryptophan (p=0.048) and kynurenine (p=0.019) and low level of IL-10 (p=0.047) in the CSF.
IBS-SSS was associated with high tumor necrosis factor and low IL-10 in the CSF; pc=0.341 and p=0.009 and pc=−0.299 and p=0.023, respectively.
Propionic minus butyric acid in faeces was negatively associated with IL-10 in the CSF (pc=−0.416, p=0.005).
Conclusions.
FGID were associated with a proinflammatory immune activation in the central nervous system and a disturbed tryptophan metabolism that could have been mediated by the faecal microbiota.
American Psychological Association (APA)
Farup, Per G.& Ueland, Thor& Rudi, Knut& Lydersen, Stian& Hestad, Knut. 2017. Functional Bowel Disorders Are Associated with a Central Immune Activation. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156164
Modern Language Association (MLA)
Farup, Per G.…[et al.]. Functional Bowel Disorders Are Associated with a Central Immune Activation. Gastroenterology Research and Practice No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1156164
American Medical Association (AMA)
Farup, Per G.& Ueland, Thor& Rudi, Knut& Lydersen, Stian& Hestad, Knut. Functional Bowel Disorders Are Associated with a Central Immune Activation. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156164