Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100)
المؤلفون المشاركون
Kase, Yoshio
Miyoshi, Jun
Nobutani, Kentaro
Musch, Mark W.
Ringus, Daina L.
Hubert, Nathaniel A.
Yamamoto, Masahiro
Nishiyama, Mitsue
Chang, Eugene
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-22
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Medications or dietary components can affect both the host and the host’s gut microbiota.
Changes in the microbiota may influence medication efficacy and interactions.
Daikenchuto (TU-100), a herbal medication, comprised of ginger, ginseng, and Japanese pepper, is widely used in Japanese traditional Kampo medicine for intestinal motility and postoperative paralytic ileus.
We previously showed in mice that consumption of TU-100 for 4 weeks changed the gut microbiota and increased bioavailability of bacterial ginsenoside metabolites.
Since TU-100 is prescribed in humans for months to years, we examined the time- and sex-dependent effects of TU-100 on mouse gut microbiota.
Oral administration of 1.5% TU-100 for 24 weeks caused more pronounced changes in gut microbiota in female than in male mice.
Changes in both sexes largely reverted to baseline upon TU-100 withdrawal.
Effects were time and dose dependent.
The microbial profiles reverted to baseline within 4 weeks after withdrawal of 0.75% TU-100 but were sustained after withdrawal of 3% TU-100.
In summary, dietary TU-100 changed mouse microbiota in a time-, sex-, and dose-dependent manner.
These findings may be taken into consideration when determining optimizing dose for conditions of human health and disease with the consideration of differences in composition and response of the human intestinal microbiota.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miyoshi, Jun& Nobutani, Kentaro& Musch, Mark W.& Ringus, Daina L.& Hubert, Nathaniel A.& Yamamoto, Masahiro…[et al.]. 2018. Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100). Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1156204
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miyoshi, Jun…[et al.]. Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100). Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1156204
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miyoshi, Jun& Nobutani, Kentaro& Musch, Mark W.& Ringus, Daina L.& Hubert, Nathaniel A.& Yamamoto, Masahiro…[et al.]. Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100). Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1156204
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156204
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر