Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100)
Joint Authors
Kase, Yoshio
Miyoshi, Jun
Nobutani, Kentaro
Musch, Mark W.
Ringus, Daina L.
Hubert, Nathaniel A.
Yamamoto, Masahiro
Nishiyama, Mitsue
Chang, Eugene
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-22
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Medications or dietary components can affect both the host and the host’s gut microbiota.
Changes in the microbiota may influence medication efficacy and interactions.
Daikenchuto (TU-100), a herbal medication, comprised of ginger, ginseng, and Japanese pepper, is widely used in Japanese traditional Kampo medicine for intestinal motility and postoperative paralytic ileus.
We previously showed in mice that consumption of TU-100 for 4 weeks changed the gut microbiota and increased bioavailability of bacterial ginsenoside metabolites.
Since TU-100 is prescribed in humans for months to years, we examined the time- and sex-dependent effects of TU-100 on mouse gut microbiota.
Oral administration of 1.5% TU-100 for 24 weeks caused more pronounced changes in gut microbiota in female than in male mice.
Changes in both sexes largely reverted to baseline upon TU-100 withdrawal.
Effects were time and dose dependent.
The microbial profiles reverted to baseline within 4 weeks after withdrawal of 0.75% TU-100 but were sustained after withdrawal of 3% TU-100.
In summary, dietary TU-100 changed mouse microbiota in a time-, sex-, and dose-dependent manner.
These findings may be taken into consideration when determining optimizing dose for conditions of human health and disease with the consideration of differences in composition and response of the human intestinal microbiota.
American Psychological Association (APA)
Miyoshi, Jun& Nobutani, Kentaro& Musch, Mark W.& Ringus, Daina L.& Hubert, Nathaniel A.& Yamamoto, Masahiro…[et al.]. 2018. Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100). Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1156204
Modern Language Association (MLA)
Miyoshi, Jun…[et al.]. Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100). Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1156204
American Medical Association (AMA)
Miyoshi, Jun& Nobutani, Kentaro& Musch, Mark W.& Ringus, Daina L.& Hubert, Nathaniel A.& Yamamoto, Masahiro…[et al.]. Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100). Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1156204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156204