Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma

المؤلفون المشاركون

Hu, Jin-Wu
Sun, Qi-Man
Fan, Jia
Zhan, Hao
Jiang, Jiahao
Ke, Aiwu
Hu, Zhiqiang
Zhu, Kai
Luo, Chubin
Ren, Ning
Zhou, Jian
Huang, Xiaowu

المصدر

Gastroenterology Research and Practice

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-11-29

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related mortality in China with increasing incidence.

This study is designed to explore early genetic changes implicated in HCC tumorigenesis and progression by whole-exome sequencing.

Methods.

We firstly sequenced the whole exomes of 5 paired hepatitis B virus-related early-stage HCC and peripheral blood samples, followed by gene ontological analysis and pathway analysis of the single-nucleotide variants discovered.

Then, the mutations of high frequency were further confirmed by Sanger sequencing.

Results.

We identified a mutational signature of dominant T:A>A:T transversion in early HCC and significantly enriched pathways including ECM-receptor interaction, axon guidance, and focal adhesion and enriched biological processes containing cell adhesion, axon guidance, and regulation of pH.

Eight genes, including MUC16, UNC79, USH2A, DNAH17, PTPN13, TENM4, PCLO, and PDE1C, were frequently mutated.

Conclusions.

This study reveals a mutational profile and a distinct mutation signature of T:A>A:T transversion in early-stage HCC with HBV infection, which will enrich our understanding of genetic characteristics of the early-stage HCC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhan, Hao& Jiang, Jiahao& Sun, Qi-Man& Ke, Aiwu& Hu, Jin-Wu& Hu, Zhiqiang…[et al.]. 2017. Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156220

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhan, Hao…[et al.]. Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma. Gastroenterology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1156220

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhan, Hao& Jiang, Jiahao& Sun, Qi-Man& Ke, Aiwu& Hu, Jin-Wu& Hu, Zhiqiang…[et al.]. Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156220

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1156220