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Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma
المؤلفون المشاركون
Hu, Jin-Wu
Sun, Qi-Man
Fan, Jia
Zhan, Hao
Jiang, Jiahao
Ke, Aiwu
Hu, Zhiqiang
Zhu, Kai
Luo, Chubin
Ren, Ning
Zhou, Jian
Huang, Xiaowu
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related mortality in China with increasing incidence.
This study is designed to explore early genetic changes implicated in HCC tumorigenesis and progression by whole-exome sequencing.
Methods.
We firstly sequenced the whole exomes of 5 paired hepatitis B virus-related early-stage HCC and peripheral blood samples, followed by gene ontological analysis and pathway analysis of the single-nucleotide variants discovered.
Then, the mutations of high frequency were further confirmed by Sanger sequencing.
Results.
We identified a mutational signature of dominant T:A>A:T transversion in early HCC and significantly enriched pathways including ECM-receptor interaction, axon guidance, and focal adhesion and enriched biological processes containing cell adhesion, axon guidance, and regulation of pH.
Eight genes, including MUC16, UNC79, USH2A, DNAH17, PTPN13, TENM4, PCLO, and PDE1C, were frequently mutated.
Conclusions.
This study reveals a mutational profile and a distinct mutation signature of T:A>A:T transversion in early-stage HCC with HBV infection, which will enrich our understanding of genetic characteristics of the early-stage HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhan, Hao& Jiang, Jiahao& Sun, Qi-Man& Ke, Aiwu& Hu, Jin-Wu& Hu, Zhiqiang…[et al.]. 2017. Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156220
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhan, Hao…[et al.]. Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma. Gastroenterology Research and Practice No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1156220
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhan, Hao& Jiang, Jiahao& Sun, Qi-Man& Ke, Aiwu& Hu, Jin-Wu& Hu, Zhiqiang…[et al.]. Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1156220
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156220
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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