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Chemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms
المؤلفون المشاركون
Abreu, Iracelle Carvalho
Silva, Selma do Nascimento
Borges, Marilene Oliveira da Rocha
Souza, Heraldo P. de
Serra, Mariana B.
Barroso, Wermerson A.
Rocha, Cláudia
Furtado, Pablo G.R.
Borges, Antônio C.R.
Tangerina, Marcelo M. P.
Nascimento, Jessyane R. do
Vilegas, Wagner
Alves, Ademilton C.
Barbeiro, Denise F.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-21
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Jacaranda decurrens Cham., known as carobinha, is prevalent in the Cerrado biome and presents popular use in treatment of dermatological diseases.
The present study aimed to investigate the healing action of topical formulation of Jacaranda decurrens Cham.
(FtEHJ) in mice cutaneous lesions.
Methods.
Phytochemical analysis of J.
decurrens hydroalcoholic extract was carried out by using HPLC-PDA-ESI-MS and FIA-ESI-IT-MSn.
Swiss mice were treated topically with formulation base (FtB) or Fibrinase® or ointment FtEHJ (15 mg/g; 50 mg/Kg).
At the end of treatment periods, the inflammatory cytokines (TNF-α, IL-1β, and IL-6) in the lesions were measured by using ELISA and gene expression of TGF-β, Collagen I, and Collagen III was demonstrated by RTqPCR method and histological evaluation.
Results.
Ten compounds were identified in the extract, distributed among the classes of flavonoids and triterpenes.
Treatment with FtEHJ increased the wound contraction in 24 hours, such as reduction of TNF-α, IL-1β, and IL-6 (pg/mL) cytokines in the lesion.
The TGF-β and collagen gene expression was increased and the wound closure accelerated to nine days, with discrete inflammation, collagenization, and accented reepithelialization.
Conclusions.
The results obtained suggest chemical compounds present in the FtEHJ accelerates wound healing by being a gene expression modulator, and protein content of different molecules are involved in tissue repair.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Serra, Mariana B.& Barroso, Wermerson A.& Rocha, Cláudia& Furtado, Pablo G.R.& Borges, Antônio C.R.& Silva, Selma do Nascimento…[et al.]. 2020. Chemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156254
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Serra, Mariana B.…[et al.]. Chemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1156254
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Serra, Mariana B.& Barroso, Wermerson A.& Rocha, Cláudia& Furtado, Pablo G.R.& Borges, Antônio C.R.& Silva, Selma do Nascimento…[et al.]. Chemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156254
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156254
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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