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Chemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms
Joint Authors
Abreu, Iracelle Carvalho
Silva, Selma do Nascimento
Borges, Marilene Oliveira da Rocha
Souza, Heraldo P. de
Serra, Mariana B.
Barroso, Wermerson A.
Rocha, Cláudia
Furtado, Pablo G.R.
Borges, Antônio C.R.
Tangerina, Marcelo M. P.
Nascimento, Jessyane R. do
Vilegas, Wagner
Alves, Ademilton C.
Barbeiro, Denise F.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Jacaranda decurrens Cham., known as carobinha, is prevalent in the Cerrado biome and presents popular use in treatment of dermatological diseases.
The present study aimed to investigate the healing action of topical formulation of Jacaranda decurrens Cham.
(FtEHJ) in mice cutaneous lesions.
Methods.
Phytochemical analysis of J.
decurrens hydroalcoholic extract was carried out by using HPLC-PDA-ESI-MS and FIA-ESI-IT-MSn.
Swiss mice were treated topically with formulation base (FtB) or Fibrinase® or ointment FtEHJ (15 mg/g; 50 mg/Kg).
At the end of treatment periods, the inflammatory cytokines (TNF-α, IL-1β, and IL-6) in the lesions were measured by using ELISA and gene expression of TGF-β, Collagen I, and Collagen III was demonstrated by RTqPCR method and histological evaluation.
Results.
Ten compounds were identified in the extract, distributed among the classes of flavonoids and triterpenes.
Treatment with FtEHJ increased the wound contraction in 24 hours, such as reduction of TNF-α, IL-1β, and IL-6 (pg/mL) cytokines in the lesion.
The TGF-β and collagen gene expression was increased and the wound closure accelerated to nine days, with discrete inflammation, collagenization, and accented reepithelialization.
Conclusions.
The results obtained suggest chemical compounds present in the FtEHJ accelerates wound healing by being a gene expression modulator, and protein content of different molecules are involved in tissue repair.
American Psychological Association (APA)
Serra, Mariana B.& Barroso, Wermerson A.& Rocha, Cláudia& Furtado, Pablo G.R.& Borges, Antônio C.R.& Silva, Selma do Nascimento…[et al.]. 2020. Chemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156254
Modern Language Association (MLA)
Serra, Mariana B.…[et al.]. Chemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1156254
American Medical Association (AMA)
Serra, Mariana B.& Barroso, Wermerson A.& Rocha, Cláudia& Furtado, Pablo G.R.& Borges, Antônio C.R.& Silva, Selma do Nascimento…[et al.]. Chemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156254