Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer
المؤلفون المشاركون
Meng, Ziqi
Liu, Xinkui
Wu, Jiarui
Wang, Kaihuan
Zhang, Xiaomeng
Duan, Xiaojiao
Zhang, Dan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-02
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Background.
Hedyotis diffusa Willd.
(HDW) is one of the renowned herbs often used in the treatment of gastric cancer (GC).
However, its curative mechanism has not been fully elucidated.
Objective.
To systematically investigate the mechanisms of HDW in GC.
Methods.
A network pharmacology approach mainly comprising target prediction, network construction, and module analysis was adopted in this study.
Results.
A total of 353 targets of the 32 bioactive compounds in HDW were obtained.
The network analysis showed that CA isoenzymes, p53, PIK3CA, CDK2, P27Kip1, cyclin D1, cyclin B1, cyclin A2, AKT1, BCL2, MAPK1, and VEGFA were identified as key targets of HDW in the treatment of GC.
The functional enrichment analysis indicated that HDW probably produced the therapeutic effects against GC by synergistically regulating many biological pathways, such as nucleotide excision repair, apoptosis, cell cycle, PI3K/AKT/mTOR signaling pathway, VEGF signaling pathway, and Ras signaling pathway.
Conclusions.
This study holistically illuminates the fact that the pharmacological mechanisms of HDW in GC might be strongly associated with its synergic modulation of apoptosis, cell cycle, differentiation, proliferation, migration, invasion, and angiogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xinkui& Wu, Jiarui& Zhang, Dan& Wang, Kaihuan& Duan, Xiaojiao& Meng, Ziqi…[et al.]. 2018. Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1156272
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xinkui…[et al.]. Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1156272
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xinkui& Wu, Jiarui& Zhang, Dan& Wang, Kaihuan& Duan, Xiaojiao& Meng, Ziqi…[et al.]. Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1156272
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156272
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر