Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer
Joint Authors
Meng, Ziqi
Liu, Xinkui
Wu, Jiarui
Wang, Kaihuan
Zhang, Xiaomeng
Duan, Xiaojiao
Zhang, Dan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Background.
Hedyotis diffusa Willd.
(HDW) is one of the renowned herbs often used in the treatment of gastric cancer (GC).
However, its curative mechanism has not been fully elucidated.
Objective.
To systematically investigate the mechanisms of HDW in GC.
Methods.
A network pharmacology approach mainly comprising target prediction, network construction, and module analysis was adopted in this study.
Results.
A total of 353 targets of the 32 bioactive compounds in HDW were obtained.
The network analysis showed that CA isoenzymes, p53, PIK3CA, CDK2, P27Kip1, cyclin D1, cyclin B1, cyclin A2, AKT1, BCL2, MAPK1, and VEGFA were identified as key targets of HDW in the treatment of GC.
The functional enrichment analysis indicated that HDW probably produced the therapeutic effects against GC by synergistically regulating many biological pathways, such as nucleotide excision repair, apoptosis, cell cycle, PI3K/AKT/mTOR signaling pathway, VEGF signaling pathway, and Ras signaling pathway.
Conclusions.
This study holistically illuminates the fact that the pharmacological mechanisms of HDW in GC might be strongly associated with its synergic modulation of apoptosis, cell cycle, differentiation, proliferation, migration, invasion, and angiogenesis.
American Psychological Association (APA)
Liu, Xinkui& Wu, Jiarui& Zhang, Dan& Wang, Kaihuan& Duan, Xiaojiao& Meng, Ziqi…[et al.]. 2018. Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1156272
Modern Language Association (MLA)
Liu, Xinkui…[et al.]. Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1156272
American Medical Association (AMA)
Liu, Xinkui& Wu, Jiarui& Zhang, Dan& Wang, Kaihuan& Duan, Xiaojiao& Meng, Ziqi…[et al.]. Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1156272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156272