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A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential
المؤلفون المشاركون
Dehelean, Cristina
Popovici, Ramona Amina
Coricovac, Dorina
Moacă, Elena-Alina
Farcaş, Claudia
Ghiţu, Alexandra
Cărăba-Meiţă, Nela-Loredana
Ardelean, Florina
Antal, Diana Simona
Avram, Ştefana
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Melissa officinalis L.
has attracted an increased interest in recent years due to its multiple pharmacological effects.
This study aimed to compare two M.
officinalis ethanolic extracts, obtained from leaves and stems, with regard to their antioxidant activity, total phenolic content, and cytotoxic effects.
M.
officinalis ethanolic extracts showed a very good antioxidant activity in the DPPH test, correlated with the content in total phenols: higher in the case of M.
officinalis from leaves extract (32.76 mg GAE/g) and lower for M.
officinalis from stems extract (8.4 mg GAE/g).
The lemon balm extracts exerted a cytotoxic effect on breast cancer cells (MDA-MB-231) even at low concentrations (100 μg/mL), whereas, in the case of healthy HaCat cells, M.
officinalis leaves extract only displayed cytotoxicity at much higher concentrations (500 and 1000 μg/mL) and M.
officinalis stems extracts were highly cytotoxic (starting at 100 μg/mL).
In addition, the extracts exerted inhibitory effects on cell migration and proliferation.
These results provide information that confirms the high potential of M.
officinalis as a source of chemopreventive agents.
Moreover, these data can be considered a solid background for further in vivo studies involving mice bearing breast tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moacă, Elena-Alina& Farcaş, Claudia& Ghiţu, Alexandra& Coricovac, Dorina& Popovici, Ramona Amina& Cărăba-Meiţă, Nela-Loredana…[et al.]. 2018. A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156295
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moacă, Elena-Alina…[et al.]. A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1156295
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moacă, Elena-Alina& Farcaş, Claudia& Ghiţu, Alexandra& Coricovac, Dorina& Popovici, Ramona Amina& Cărăba-Meiţă, Nela-Loredana…[et al.]. A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156295
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156295
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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