A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential
Joint Authors
Dehelean, Cristina
Popovici, Ramona Amina
Coricovac, Dorina
Moacă, Elena-Alina
Farcaş, Claudia
Ghiţu, Alexandra
Cărăba-Meiţă, Nela-Loredana
Ardelean, Florina
Antal, Diana Simona
Avram, Ştefana
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Melissa officinalis L.
has attracted an increased interest in recent years due to its multiple pharmacological effects.
This study aimed to compare two M.
officinalis ethanolic extracts, obtained from leaves and stems, with regard to their antioxidant activity, total phenolic content, and cytotoxic effects.
M.
officinalis ethanolic extracts showed a very good antioxidant activity in the DPPH test, correlated with the content in total phenols: higher in the case of M.
officinalis from leaves extract (32.76 mg GAE/g) and lower for M.
officinalis from stems extract (8.4 mg GAE/g).
The lemon balm extracts exerted a cytotoxic effect on breast cancer cells (MDA-MB-231) even at low concentrations (100 μg/mL), whereas, in the case of healthy HaCat cells, M.
officinalis leaves extract only displayed cytotoxicity at much higher concentrations (500 and 1000 μg/mL) and M.
officinalis stems extracts were highly cytotoxic (starting at 100 μg/mL).
In addition, the extracts exerted inhibitory effects on cell migration and proliferation.
These results provide information that confirms the high potential of M.
officinalis as a source of chemopreventive agents.
Moreover, these data can be considered a solid background for further in vivo studies involving mice bearing breast tumors.
American Psychological Association (APA)
Moacă, Elena-Alina& Farcaş, Claudia& Ghiţu, Alexandra& Coricovac, Dorina& Popovici, Ramona Amina& Cărăba-Meiţă, Nela-Loredana…[et al.]. 2018. A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156295
Modern Language Association (MLA)
Moacă, Elena-Alina…[et al.]. A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1156295
American Medical Association (AMA)
Moacă, Elena-Alina& Farcaş, Claudia& Ghiţu, Alexandra& Coricovac, Dorina& Popovici, Ramona Amina& Cărăba-Meiţă, Nela-Loredana…[et al.]. A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156295