Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking
المؤلفون المشاركون
Lou, Yan
Liu, Shanghui
Liu, Jia
Wang, Run
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-07
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Pien-Tze-Huang (PTH) has a long history in the treatment of liver cancer.
However, its molecular mechanism of action remains unclear.
TCMSP and TCM were used to collect the active ingredients.
Bioactive compounds targets were predicted by reverse pharmacophore models.
The antiliver cancer targets of PTH were selected by gene comparison of liver cancer in the GEO database.
Molecular docking was used to verify the binding activity of the targets and the active ingredients.
The DAVID was used to analyze the gene function and signal pathway.
A model was built with Cytoscape.
The core genes were obtained by PPI network.
We screened the 4 main medicinal ingredients of PTH to obtain 16 active ingredient, 190 potential targets, and 6 core genes.
We found that active small molecules exert anticancer effects by multiple pathways.
The core genes were involved in multiple biological processes.
We also found that eight chemical components play a greater role in inhibiting liver cancer.
PTH achieves the effect of inhibiting liver cancer through the synergistic effect of multiple components, multiple targets, and multiple pathways.
This study provides a potential scientific basis for further elucidating the molecular mechanism of action of PTH against liver cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Shanghui& Wang, Run& Lou, Yan& Liu, Jia. 2020. Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156299
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Shanghui…[et al.]. Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1156299
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Shanghui& Wang, Run& Lou, Yan& Liu, Jia. Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156299
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156299
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر