Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking
Joint Authors
Lou, Yan
Liu, Shanghui
Liu, Jia
Wang, Run
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Pien-Tze-Huang (PTH) has a long history in the treatment of liver cancer.
However, its molecular mechanism of action remains unclear.
TCMSP and TCM were used to collect the active ingredients.
Bioactive compounds targets were predicted by reverse pharmacophore models.
The antiliver cancer targets of PTH were selected by gene comparison of liver cancer in the GEO database.
Molecular docking was used to verify the binding activity of the targets and the active ingredients.
The DAVID was used to analyze the gene function and signal pathway.
A model was built with Cytoscape.
The core genes were obtained by PPI network.
We screened the 4 main medicinal ingredients of PTH to obtain 16 active ingredient, 190 potential targets, and 6 core genes.
We found that active small molecules exert anticancer effects by multiple pathways.
The core genes were involved in multiple biological processes.
We also found that eight chemical components play a greater role in inhibiting liver cancer.
PTH achieves the effect of inhibiting liver cancer through the synergistic effect of multiple components, multiple targets, and multiple pathways.
This study provides a potential scientific basis for further elucidating the molecular mechanism of action of PTH against liver cancer.
American Psychological Association (APA)
Liu, Shanghui& Wang, Run& Lou, Yan& Liu, Jia. 2020. Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156299
Modern Language Association (MLA)
Liu, Shanghui…[et al.]. Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1156299
American Medical Association (AMA)
Liu, Shanghui& Wang, Run& Lou, Yan& Liu, Jia. Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156299