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Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study
المؤلفون المشاركون
Schäfer, Markus
Slieker, Juliette C.
Aellen, Steve
Eggimann, Philippe
Guarnero, Valentine
Demartines, Nicolas
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Serum procalcitonin (PCT) is a useful biomarker to tailor the duration of antibiotics in respiratory infections.
The objective of this study was to determine whether PCT levels could tailor postoperative antibiotic therapy in patients operated for peritonitis.
Method.
Patients with peritonitis were randomized postoperatively.
The control group received antibiotics for a defined duration according to institutional guidelines.
In the study group, antibiotics were stopped based on serum PCT levels.
Patients were stratified into three categories: (1) gastrointestinal perforation, (2) perforated appendicitis, and (3) postoperative complication.
Primary outcome was duration of antibiotics.
Results.
We included 162 patients: 83 and 79 patients in the control group and study group, respectively.
In the subgroup of patients with peritonitis due to gastrointestinal perforation, we found 7 days of antibiotics in the PCT group versus 10 days in the control group (p value 0.065).
There was no difference in infectious complications, mortality, median length of hospital stay, and necessity to restart antibiotics.
Conclusion.
No significant differences were found in duration of antibiotics when applying PCT guidance.
However, in the subgroup of primary perforation of the gastrointestinal tract, there was a difference in duration of antibiotics in favor of the PCT group without obtaining significance, as the study was not powered for subgroup analysis.
Further studies including only this subgroup should be performed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Slieker, Juliette C.& Aellen, Steve& Eggimann, Philippe& Guarnero, Valentine& Schäfer, Markus& Demartines, Nicolas. 2017. Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156323
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Slieker, Juliette C.…[et al.]. Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study. Gastroenterology Research and Practice No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1156323
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Slieker, Juliette C.& Aellen, Steve& Eggimann, Philippe& Guarnero, Valentine& Schäfer, Markus& Demartines, Nicolas. Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156323
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156323
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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