Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study
Joint Authors
Schäfer, Markus
Slieker, Juliette C.
Aellen, Steve
Eggimann, Philippe
Guarnero, Valentine
Demartines, Nicolas
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Serum procalcitonin (PCT) is a useful biomarker to tailor the duration of antibiotics in respiratory infections.
The objective of this study was to determine whether PCT levels could tailor postoperative antibiotic therapy in patients operated for peritonitis.
Method.
Patients with peritonitis were randomized postoperatively.
The control group received antibiotics for a defined duration according to institutional guidelines.
In the study group, antibiotics were stopped based on serum PCT levels.
Patients were stratified into three categories: (1) gastrointestinal perforation, (2) perforated appendicitis, and (3) postoperative complication.
Primary outcome was duration of antibiotics.
Results.
We included 162 patients: 83 and 79 patients in the control group and study group, respectively.
In the subgroup of patients with peritonitis due to gastrointestinal perforation, we found 7 days of antibiotics in the PCT group versus 10 days in the control group (p value 0.065).
There was no difference in infectious complications, mortality, median length of hospital stay, and necessity to restart antibiotics.
Conclusion.
No significant differences were found in duration of antibiotics when applying PCT guidance.
However, in the subgroup of primary perforation of the gastrointestinal tract, there was a difference in duration of antibiotics in favor of the PCT group without obtaining significance, as the study was not powered for subgroup analysis.
Further studies including only this subgroup should be performed.
American Psychological Association (APA)
Slieker, Juliette C.& Aellen, Steve& Eggimann, Philippe& Guarnero, Valentine& Schäfer, Markus& Demartines, Nicolas. 2017. Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156323
Modern Language Association (MLA)
Slieker, Juliette C.…[et al.]. Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study. Gastroenterology Research and Practice No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1156323
American Medical Association (AMA)
Slieker, Juliette C.& Aellen, Steve& Eggimann, Philippe& Guarnero, Valentine& Schäfer, Markus& Demartines, Nicolas. Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156323